Ozturk Zeynep, Olmez Ercument, Gurpinar Tugba, Vural Kamil
Department of Clinical Pharmacology and Toxicology, Izmir Ataturk Research Hospital, Izmir, Turkey.
Department of Medical Pharmacology, Celal Bayar University, Manisa, Turkey.
Reprod Toxicol. 2016 Apr;60:129-32. doi: 10.1016/j.reprotox.2016.02.004. Epub 2016 Feb 12.
Thiocolchicoside is a commonly used muscle relaxant in orthopedic, rheumatologic or musculoskeletal disorders to treat painful muscle spasms. It is contraindicated in pregnancy and lactation. There is no previously published experience with thiocolchicoside exposure during pregnancy. In this observational study, we collected and evaluated 18 pregnancy outcomes of the women referred to our prenatal consultation service for thiocolchicoside exposure between 2007-2012, and offspring were followed up until 2 years of age. There were 16 live births, 1 spontaneous abortion and 1 elective termination of pregnancy. No major birth defect was observed. The mothers and their babies were free of perinatal complications. No growth or developmental abnormalities were found during follow-up period. Our findings add information on inadvertent use of thiocolchicoside in pregnancy. Further large prospective cohort studies are required to investigate this issue.
硫代秋水仙苷是一种常用于治疗骨科、风湿科或肌肉骨骼疾病中疼痛性肌肉痉挛的肌肉松弛剂。它在妊娠和哺乳期禁用。此前尚无关于孕期接触硫代秋水仙苷的报道。在这项观察性研究中，我们收集并评估了2007年至2012年间因接触硫代秋水仙苷而转诊至我们产前咨询服务处的18名妇女的妊娠结局，并对其后代进行随访至2岁。有16例活产、1例自然流产和1例选择性终止妊娠。未观察到重大出生缺陷。母亲及其婴儿均无围产期并发症。随访期间未发现生长或发育异常。我们的研究结果补充了孕期意外使用硫代秋水仙苷的相关信息。需要进一步开展大型前瞻性队列研究来调查这个问题。
