Shankman Stewart A, Katz Andrea C, Langenecker Scott A
Department of Psychology and Psychiatry, University of Illinois-Chicago, Chicago, Illinois, USA.
Psychophysiology. 2016 Mar;53(3):328-31. doi: 10.1111/psyp.12590.
The Research Domain Criteria (RDoC) initiative put forth by the National Institute of Mental Health represents an exciting new framework in which to study psychopathology. The article by Hamm et al. (2016) is an interesting application of an "RDoC lens" toward a program of research on panic disorder. This commentary highlights the many strengths of the Hamm et al. (2016) study-most notably the article's application of a well-studied animal model of anxiety (Fanselow's, , threat imminence model) to humans, utilization of an interesting behavioral paradigm (as an analog for avoidance behaviors in panic disorder), and using RDoC to examine predictors of treatment response. This commentary also discusses several questions about RDoC that arise out of Hamm et al. For example, (a) How should participants be selected for RDoC studies? (b) Are RDoC constructs risk factors (and risk factors for what)? (c) Besides Hamm et al.'s, approach, how else can RDoC be used in treatment studies? In sum, Hamm et al. is a very good example of an RDoC study, and in this early phase of the initiative, more examples for how the approach plays out are needed.
美国国立精神卫生研究所提出的研究领域标准（RDoC）计划代表了一个用于研究精神病理学的令人兴奋的新框架。哈姆等人（2016年）的文章是“RDoC视角”在惊恐障碍研究项目中的一个有趣应用。本评论突出了哈姆等人（2016年）研究的诸多优点——最显著的是该文章将一个经过充分研究的焦虑动物模型（范瑟洛的威胁逼近模型）应用于人类，采用了一种有趣的行为范式（作为惊恐障碍中回避行为的类似物），并利用RDoC来检验治疗反应的预测因素。本评论还讨论了由哈姆等人的研究引发的几个关于RDoC的问题。例如，（a）应如何为RDoC研究选择参与者？（b）RDoC结构是风险因素吗（以及是什么的风险因素）？（c）除了哈姆等人的方法外，RDoC还能如何用于治疗研究？总之，哈姆等人的研究是RDoC研究的一个很好的例子，在该计划的这个早期阶段，还需要更多关于该方法如何发挥作用的例子。
