Vázquez-Arreguín Karina, Tantin Dean
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Biochim Biophys Acta. 2016 Jun;1859(6):792-804. doi: 10.1016/j.bbagrm.2016.02.007. Epub 2016 Feb 10.
The metazoan-specific POU domain transcription factor family comprises activities underpinning developmental processes such as embryonic pluripotency and neuronal specification. Some POU family proteins efficiently bind an 8-bp DNA element known as the octamer motif. These proteins are known as Oct transcription factors. Oct1/POU2F1 is the only widely expressed POU factor. Unlike other POU factors it controls no specific developmental or organ system. Oct1 was originally described to operate at target genes associated with proliferation and immune modulation, but more recent results additionally identify targets associated with oxidative and cytotoxic stress resistance, metabolic regulation, stem cell function and other unexpected processes. Oct1 is pro-oncogenic in multiple contexts, and several recent reports provide broad evidence that Oct1 has prognostic and therapeutic value in multiple epithelial tumor settings. This review focuses on established and emerging roles of Oct1 in epithelial tumors, with an emphasis on mechanisms of transcription regulation by Oct1 that may underpin these findings. This article is part of a Special Issue entitled: The Oct Transcription Factor Family, edited by Dr. Dean Tantin.
后生动物特有的POU结构域转录因子家族包含支持胚胎多能性和神经元特化等发育过程的活性。一些POU家族蛋白能有效结合一种被称为八聚体基序的8碱基对DNA元件。这些蛋白被称为Oct转录因子。Oct1/POU2F1是唯一广泛表达的POU因子。与其他POU因子不同，它不控制特定的发育或器官系统。Oct1最初被描述为在与增殖和免疫调节相关的靶基因上起作用，但最近的研究结果还发现了与氧化和细胞毒性应激抗性、代谢调节、干细胞功能及其他意外过程相关的靶标。Oct1在多种情况下具有促癌作用，最近的几份报告提供了广泛的证据，表明Oct1在多种上皮肿瘤环境中具有预后和治疗价值。本综述重点关注Oct1在上皮肿瘤中已确立和新出现的作用，重点是Oct1可能支持这些发现的转录调控机制。本文是由迪恩·坦廷博士编辑的名为《Oct转录因子家族》特刊的一部分。
