Sun Xi-peng, Li Bo-yu, Li Jing, Zhu Wei-wei, Hua Qi
Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 100053.
Sci Rep. 2016 Feb 16;6:21350. doi: 10.1038/srep21350.
We investigated the association between mean platelet volume (MPV) and risk of all-cause mortality in Chinese patients with ST-Elevation Myocardial Infarction (STEMI). We enrolled 1836 patients with STEMI in Xuanwu Hospital from January 2008 to December 2013. Based on MPV, patients were categorized into the following groups: < 9.5 fL (n = 85), 9.5-11.0 fL (n = 776), 11.1-12.5 fL (n = 811) and >12.5 fL (n = 164), respectively. Mean duration of follow-up was 56.9 months, and 197 patients (10.7%) died during follow-up. All-cause mortality rates were compared between groups. The lowest mortality occurred in patients with MPV between 9.5-11.0 fL, with a multivariable-adjusted hazard ratio (HR) of 1.15(95%CI 0.62-1.50), 1.38(95%CI 1.20-1.68), and 1.72(95%CI 1.41-1.96) in patients with MPV of <.5, 11.1-12.5 and >12.5 fL, respectively. Therefore, increased MPV was associated with all-cause mortality in Chinese patients with STEMI. MPV might be useful as a marker for risk stratification in Chinese patients with STEMI.
我们研究了中国ST段抬高型心肌梗死（STEMI）患者的平均血小板体积（MPV）与全因死亡率风险之间的关联。2008年1月至2013年12月期间，我们在宣武医院招募了1836例STEMI患者。根据MPV，患者被分为以下几组：<9.5 fL（n = 85）、9.5 - 11.0 fL（n = 776）、11.1 - 12.5 fL（n = 811）和>12.5 fL（n = 164）。平均随访时间为56.9个月，197例患者（10.7%）在随访期间死亡。比较了各组之间的全因死亡率。MPV在9.5 - 11.0 fL之间的患者死亡率最低，MPV <9.5、11.1 - 12.5和>12.5 fL的患者多变量调整后的风险比（HR）分别为上1.15（95%CI 0.62 - 1.50）、1.38（95%CI 1.20 - 1.68）和1.72（95%CI 1.41 - 1.96）。因此，在中国STEMI患者中，MPV升高与全因死亡率相关。MPV可能作为中国STEMI患者风险分层的一个标志物。
