Abdel Hadi Loubna, Di Vito Clara, Riboni Laura
Department of Medical Biotechnology and Translational Medicine, LITA-Segrate, University of Milan, 20090 Milan, Italy.
Mediators Inflamm. 2016;2016:3827684. doi: 10.1155/2016/3827684. Epub 2016 Jan 5.
Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in numerous cellular events, including intestinal cell survival, growth, differentiation, and apoptosis. A significant body of knowledge demonstrates that intestinal sphingolipids play a crucial role, as such and through their signaling pathways, in immunity and inflammatory disorders. In this review, we report on and discuss the current knowledge on the metabolism, signaling, and functional implications of sphingolipids in inflammatory bowel disease (IBD), focusing on the different aspects of sphingolipid actions on inflammatory responses and on the potential of sphingolipid-targeted molecules as anti-IBD therapeutic agents.
复杂鞘脂是肠膜的重要结构成分，为肠黏膜提供保护和完整性，并调节肠道吸收过程。鞘脂信号传导在众多细胞事件中发挥作用，包括肠道细胞存活、生长、分化和凋亡。大量知识表明，肠道鞘脂本身及其信号通路在免疫和炎症性疾病中起着关键作用。在本综述中，我们报告并讨论了目前关于鞘脂在炎症性肠病（IBD）中的代谢、信号传导和功能影响的知识，重点关注鞘脂对炎症反应作用的不同方面以及鞘脂靶向分子作为抗IBD治疗药物的潜力。
