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中国北京高甘油三酯性胰腺炎特征的回顾性研究

A Retrospective Research of the Characteristic of Hypertriglyceridemic Pancreatitis in Beijing, China.

作者信息

Tai Wei-Ping, Lin Xiang-Chun, Liu Hong, Wang Cang-Hai, Wu Jing, Zhang Neng-Wei, Chen Wei

机构信息

Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University Beijing 100038, China.

Department of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

出版信息

Gastroenterol Res Pract. 2016;2016:6263095. doi: 10.1155/2016/6263095. Epub 2016 Jan 5.

Abstract

Aim. To investigate the characteristic of hypertriglyceridemic- (HTG-) induced pancreatitis (HTG pancreatitis). Methods. We reviewed 126 cases of HTG pancreatitis and 168 cases of biliary pancreatitis as control. Results. The HTG group mean age was younger than biliary group. The number of females was a little higher than males in both groups. There were 18 cases that were recurrent in HTG group and 11 in billiary group. The mean hospitalization times were 13.7 ± 2.6 and 11.2 ± 2.3 days in two groups. Six patients received apheresis in HTG group. The proportion of severe AP was 31.0% and 26.2%, mortality 1.6% and 1.2%, comorbidity of diabetes mellitus (DM) 20.6% and 6.5% in two groups. The number of complications of gastrointestinal (GI) bleeding, sepsis, and multiple organ dysfunction syndrome (MODS) in HTG group and biliary group was 1, 1, and 2 versus 4, 12, and 4. Conclusions. The proportion of recurrent and severe AP and comorbidity of DM of HTG group was higher than billiary group. The proportion of the complications of GI bleeding, sepsis, and MODS of HTG group was less than biliary group. Apheresis could effectively reduce serum TG levels soon. There was no significant difference of the mortality between two groups.

摘要

目的。探讨高甘油三酯血症(HTG)诱发的胰腺炎(HTG胰腺炎)的特点。方法。我们回顾了126例HTG胰腺炎病例,并以168例胆源性胰腺炎病例作为对照。结果。HTG组的平均年龄比胆源性组年轻。两组中女性人数均略高于男性。HTG组有18例复发,胆源性组有11例复发。两组的平均住院时间分别为13.7±2.6天和11.2±2.3天。HTG组有6例患者接受了血液滤过治疗。两组中重症急性胰腺炎(AP)的比例分别为31.0%和26.2%,死亡率分别为1.6%和1.2%,糖尿病(DM)合并症的比例分别为20.6%和6.5%。HTG组和胆源性组胃肠道(GI)出血、脓毒症和多器官功能障碍综合征(MODS)的并发症数量分别为1、1和2例,而胆源性组分别为4、12和4例。结论。HTG组AP复发和重症的比例以及DM合并症的比例高于胆源性组。HTG组GI出血、脓毒症和MODS并发症的比例低于胆源性组。血液滤过可迅速有效降低血清甘油三酯水平。两组之间的死亡率无显著差异。

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