Meena Mahesh Chand, Hemal Alok, Satija Mukul, Arora Shilpa Khanna, Bano Shahina
Department of Pediatrics, PGIMER and Dr. RML Hospital, New Delhi 110001, India.
Department of Radiology, PGIMER and Dr. RML Hospital, New Delhi 110001, India.
Adv Hematol. 2015;2015:648349. doi: 10.1155/2015/648349. Epub 2015 Dec 31.
Chronic hemoglobinopathies like thalassemia are associated with many osteopathies like osteoporosis. Methods. This observational study was carried out to compare the bone mineral density (BMD) in transfusion dependent thalassemics with that of healthy controls. Thirty-two thalassemia patients, aged 2-18 years, and 32 age and sex matched controls were studied. The bone mineral concentration (BMC) and BMD were assessed at lumbar spine, distal radius, and neck of femur. Biochemical parameters like serum calcium and vitamin D levels were also assessed. Results. The BMC of neck of femur was significantly low in cases in comparison to controls. We also observed significantly lower BMD at the lumbar spine in cases in comparison to controls. A significantly positive correlation was observed between serum calcium levels and BMD at neck of femur. Conclusion. Hence, low serum calcium may be used as a predictor of low BMD especially in populations where incidence of hypovitaminosis D is very high.
像地中海贫血这样的慢性血红蛋白病与许多骨病如骨质疏松症相关。方法。本观察性研究旨在比较依赖输血的地中海贫血患者与健康对照者的骨密度（BMD）。研究了32名年龄在2至18岁的地中海贫血患者以及32名年龄和性别匹配的对照者。在腰椎、桡骨远端和股骨颈评估骨矿物质浓度（BMC）和BMD。还评估了血清钙和维生素D水平等生化参数。结果。与对照组相比，病例组股骨颈的BMC显著降低。我们还观察到，与对照组相比，病例组腰椎的BMD也显著降低。血清钙水平与股骨颈BMD之间存在显著正相关。结论。因此，低血清钙可作为低BMD的预测指标，尤其是在维生素D缺乏症发病率非常高的人群中。
