《与烟酰胺腺嘌呤二核苷酸（NAD(+)）及一种吲哚（EX527类似物）结合的SIRT1催化结构域的2.5埃晶体结构修正揭示了组蛋白去乙酰化酶抑制的新机制》的勘误 - Suppr

Correction to The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD(+)) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition.

作者信息

Zhao Xun, Allison Dagart, Condon Bradley, Zhang Feiyu, Gheyi Tarun, Zhang Aiping, Ashok Sheela, Russell Marijane, MacEwan Iain, Qian Yuewei, Jamison James A, Luz John Gately

出版信息

J Med Chem. 2016 Mar 10;59(5):2267. doi: 10.1021/acs.jmedchem.6b00130. Epub 2016 Feb 16.

DOI:10.1021/acs.jmedchem.6b00130

PMID:26882000

Abstract

摘要

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Correction to The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD(+)) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition.《与烟酰胺腺嘌呤二核苷酸（NAD(+)）及一种吲哚（EX527类似物）结合的SIRT1催化结构域的2.5埃晶体结构修正揭示了组蛋白去乙酰化酶抑制的新机制》的勘误

J Med Chem. 2016 Mar 10;59(5):2267. doi: 10.1021/acs.jmedchem.6b00130. Epub 2016 Feb 16.

The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.SIRT1 催化结构域与烟酰胺腺嘌呤二核苷酸（NAD+）和一个吲哚（EX527 类似物）结合的 2.5 Å 晶体结构揭示了组蛋白去乙酰化酶抑制的新机制。

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Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins).作为NAD+依赖的组蛋白去乙酰化酶（沉默调节蛋白）抑制剂的苏拉明类似物的构效关系研究

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Exogenous NAD(+) supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway.外源性补充烟酰胺腺嘌呤二核苷酸（NAD(+)）通过沉默信息调节因子1（Sirt1）- 抑癌基因p53（p53）途径保护H9c2心肌成肌细胞免受缺氧/复氧损伤。

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A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide.通过定量烟酰胺腺嘌呤二核苷酸检测 SIRT1 脱乙酰化活性的荧光分析方法。

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Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.大鼠肝脏S-腺苷同型半胱氨酸水解酶的晶体结构。

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Characterization of oxidized nicotinamide adenine dinucleotide (NAD(+)) analogues using a high-pressure-liquid-chromatography-based NAD(+)-glycohydrolase assay and comparison with fluorescence-based measurements.

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Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.烟酰胺腺嘌呤二核苷酸类似物的二核苷二硫化物模拟物对烟酰胺腺嘌呤二核苷酸激酶的选择性抑制作用。

Bioorg Med Chem. 2009 Aug 1;17(15):5656-64. doi: 10.1016/j.bmc.2009.06.013. Epub 2009 Jun 13.

Probing Aplysia californica adenosine 5'-diphosphate ribosyl cyclase for substrate binding requirements: design of potent inhibitors.探索加州海兔5'-二磷酸腺苷核糖基环化酶的底物结合需求：强效抑制剂的设计

Biochemistry. 1999 Jul 13;38(28):9105-14. doi: 10.1021/bi9903392.

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Correction to The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD(+)) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition.

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