室温下通过基础金属催化直接二氟甲基化芳基卤化物。
Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature.
机构信息
Department of Chemistry, Lehigh University , 6 East Packer Avenue, Bethlehem, Pennsylvania 18015, United States.
出版信息
J Am Chem Soc. 2016 Mar 2;138(8):2536-9. doi: 10.1021/jacs.6b00053. Epub 2016 Feb 18.
PMID:26883690
Abstract
A stable and isolable difluoromethyl zinc reagent has been prepared through the reaction of ICF2H with diethyl zinc and DMPU. This new zinc reagent is a free-flowing solid and can be used in combination with a nickel catalyst to difluoromethylate aryl iodides, bromides, and triflates at room temperature. Such mild conditions for the catalytic difluoromethylation of these substrates are unprecedented.
摘要
一种稳定且可分离的二氟甲基锌试剂已通过 ICF2H 与二乙基锌和 DMPU 的反应制备得到。这种新型锌试剂为可自由流动的固体，可与镍催化剂结合使用，在室温下对芳基碘化物、溴化物和三氟甲磺酸酯进行二氟甲基化。这种温和的条件对于这些底物的催化二氟甲基化是前所未有的。
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