2015年来自科罗拉多州德尔塔的耐碳青霉烯类和耐黏菌素阴沟肠杆菌
Carbapenem- and Colistin-Resistant Enterobacter cloacae from Delta, Colorado, in 2015.
作者信息
Norgan Andrew P, Freese Jarred M, Tuin Patricia M, Cunningham Scott A, Jeraldo Patricio R, Patel Robin
机构信息
Department of Laboratory Medicine and Pathology, Rochester, Minnesota, USA.
Delta County Memorial Hospital, Delta, Colorado, USA.
出版信息
Antimicrob Agents Chemother. 2016 Apr 22;60(5):3141-4. doi: 10.1128/AAC.03055-15. Print 2016 May.
Abstract
Resistance to carbapenems in Enterobacteriaceae is a clinical problem of growing significance. Difficulty in treating multidrug-resistant Gram-negative organisms with conventional antibiotics has led to a renewed and increasing use of polymyxin compounds, such as colistin. Here, we report the isolation of carbapenem- and colistin-resistant Enterobacter cloacae from a polymicrobial lower extremity wound in an ambulatory patient. Whole-genome sequencing demonstrated the presence of chromosomal blaIMI-1 and blaAmpC, as well as numerous efflux pump genes.
摘要
肠杆菌科细菌对碳青霉烯类抗生素的耐药性是一个日益重要的临床问题。使用传统抗生素治疗多重耐药革兰氏阴性菌存在困难，这导致了多粘菌素类化合物（如黏菌素）的重新使用且用量不断增加。在此，我们报告从一名门诊患者的多微生物性下肢伤口中分离出对碳青霉烯类和黏菌素耐药的阴沟肠杆菌。全基因组测序显示存在染色体blaIMI-1和blaAmpC，以及众多外排泵基因。
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