新加坡五年研究期间 - 阳性阴沟肠杆菌复合体的基因组研究。
Genomic Study of -Positive Enterobacter cloacae Complex in Singapore over a Five-Year Study Period.
机构信息
National Public Health Laboratory, National Center for Infectious Diseases, Singapore.
National Centre for Infectious Diseases, Singapore.
出版信息
Antimicrob Agents Chemother. 2020 Jul 22;64(8). doi: 10.1128/AAC.00510-20.
Abstract
The gene is rarely detected outside the genus. Genomic characterization of 87 -positive complex members revealed that the largest phylogenomic clade was made up of subsp. (71.3%), followed by the newly described species (13.8%), (10.3%), and (4.6%). IMI-1 was the predominant carbapenemase variant (86/87, 98.9%). All the genes were associated with chromosomally integrated Xer-dependent integrative mobile elements (IMEXs), with two new variants detected.
摘要
该基因在属外很少被检测到。对 87 株阳性复合体成员的基因组特征分析表明，最大的系统发育分支由 亚种（71.3%）组成，其次是新描述的种 （13.8%）、 （10.3%）和 （4.6%）。IMI-1 是主要的碳青霉烯酶变异体（87/87，98.9%）。所有的 基因都与染色体整合的 Xer 依赖型整合移动元件（IMEXs）有关，检测到两种新的变体。
相似文献
1
Genomic Study of -Positive Enterobacter cloacae Complex in Singapore over a Five-Year Study Period.新加坡五年研究期间 - 阳性阴沟肠杆菌复合体的基因组研究。
Antimicrob Agents Chemother. 2020 Jul 22;64(8). doi: 10.1128/AAC.00510-20.
2
Outbreak of IMI-1 carbapenemase-producing colistin-resistant Enterobacter cloacae on the French island of Mayotte (Indian Ocean).印度洋马约特岛爆发产 IMI-1 碳青霉烯酶多黏菌素耐药阴沟肠杆菌感染。
Int J Antimicrob Agents. 2018 Sep;52(3):416-420. doi: 10.1016/j.ijantimicag.2018.05.015. Epub 2018 May 26.
3
Enterobacter cloacae producing an uncommon class A carbapenemase, IMI-1, from Singapore.新加坡产 IMI-1 的阴沟肠杆菌，一种不常见的 A 类碳青霉烯酶。
J Med Microbiol. 2013 Jul;62(Pt 7):1086-1088. doi: 10.1099/jmm.0.053363-0. Epub 2013 Apr 4.
4
IMI-Type Carbapenemase-Producing Enterobacter cloacae Complex, France and Overseas Regions, 2012-2022.2012-2022 年法国及其海外领地产 IMI 型碳青霉烯酶肠杆菌科复合群。
Emerg Infect Dis. 2024 Jun;30(6):1279-1282. doi: 10.3201/eid3006.231525.
5
The occurrence and genomic characteristics of the blaIMI-1 carbapenemase-producing Enterobacter cloacae complex retrieved from natural water sources in central Thailand.从中泰中部天然水源中分离出的产 blaIMI-1 碳青霉烯酶阴沟肠杆菌复合体的发生和基因组特征。
J Appl Microbiol. 2023 Oct 4;134(10). doi: 10.1093/jambio/lxad229.
6
First identification of an IMI-1 carbapenemase-producing colistin-resistant Enterobacter cloacae in China.中国首次鉴定出一株产IMI-1碳青霉烯酶的耐黏菌素阴沟肠杆菌。
Ann Clin Microbiol Antimicrob. 2015 Nov 25;14:51. doi: 10.1186/s12941-015-0112-2.
7
Enterobacter cloacae Complex Isolates Harboring or -Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids.阴沟肠杆菌复合体分离株在新型染色体整合元件和质粒上携带OXA或KPC型A类碳青霉烯酶基因。
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02578-16. Print 2017 May.
8
Emergence of VIM-1-carbapenemase-producing Enterobacter cloacae in Tyrol, Austria.奥地利蒂罗尔州出现产 VIM-1 碳青霉烯酶的阴沟肠杆菌。
J Med Microbiol. 2012 Apr;61(Pt 4):567-571. doi: 10.1099/jmm.0.038646-0. Epub 2011 Dec 22.
9
Characterization of a Novel Putative Xer-Dependent Integrative Mobile Element Carrying the bla(NMC-A) Carbapenemase Gene, Inserted into the Chromosome of Members of the Enterobacter cloacae Complex.一种携带bla(NMC-A)碳青霉烯酶基因的新型假定Xer依赖性整合移动元件的特性分析，该元件插入阴沟肠杆菌复合体成员的染色体中。
Antimicrob Agents Chemother. 2015 Oct;59(10):6620-4. doi: 10.1128/AAC.01452-15. Epub 2015 Jul 27.
10
Identification of a novel IMI carbapenemase variant (IMI-9) in Enterobacter cloacae complex.在阴沟肠杆菌复合体中鉴定出一种新型IMI碳青霉烯酶变体（IMI-9）。
Int J Antimicrob Agents. 2016 Dec;48(6):764-765. doi: 10.1016/j.ijantimicag.2016.09.004. Epub 2016 Sep 29.
引用本文的文献
1
Next-Gen Nano Biosensor Technologies to Monitor Carbapenem Resistance for Personalized Medicine.用于个性化医疗的监测碳青霉烯类耐药性的下一代纳米生物传感器技术
Indian J Microbiol. 2025 Mar;65(1):277-296. doi: 10.1007/s12088-024-01337-z. Epub 2024 Jun 20.
2
First identification and whole-genome characterization of human-associated Enterobacter roggenkampii and Enterobacter sichuanensis carrying bla carbapenemase in Costa Rica.在哥斯达黎加首次鉴定并对携带碳青霉烯酶的人源罗根坎普肠杆菌和四川肠杆菌进行全基因组特征分析。
J Glob Antimicrob Resist. 2025 Jun;43:68-75. doi: 10.1016/j.jgar.2025.04.004. Epub 2025 Apr 14.
3
IMI-Type Carbapenemase-Producing Enterobacter cloacae Complex, France and Overseas Regions, 2012-2022.2012-2022 年法国及其海外领地产 IMI 型碳青霉烯酶肠杆菌科复合群。
Emerg Infect Dis. 2024 Jun;30(6):1279-1282. doi: 10.3201/eid3006.231525.
4
Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria.尼日利亚孕妇和新生儿肠道革兰氏阴性菌中多粘菌素耐药性的特征。
Nat Commun. 2024 Mar 14;15(1):2302. doi: 10.1038/s41467-024-45673-6.
5
Prevalence and Abundance of Beta-Lactam Resistance Genes in Hospital Wastewater and Enterobacterales Wastewater Isolates.医院废水和肠杆菌科废水分离物中β-内酰胺抗性基因的流行率和丰度
Trop Med Infect Dis. 2023 Mar 27;8(4):193. doi: 10.3390/tropicalmed8040193.
6
Complete Genome Sequence of Enterobacter roggenkampii RX.G5M56, a C1-Metabolizing Strain from a Freshwater Stream in Hong Kong.罗根坎普肠杆菌RX.G5M56的全基因组序列，该菌株来自香港一条淡水溪流，具有C1代谢能力
Microbiol Resour Announc. 2023 Apr 18;12(4):e0001523. doi: 10.1128/mra.00015-23. Epub 2023 Mar 15.
7
A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital.以色列一家医院发生广泛传播的产 IMI-17 型阴沟肠杆菌感染
Antimicrob Resist Infect Control. 2021 Nov 29;10(1):166. doi: 10.1186/s13756-021-01036-0.
本文引用的文献
1
Occurrence of carbapenemase-producing Enterobacteriaceae in a Portuguese river: bla, bla and bla among the detected genes.产碳青霉烯酶肠杆菌科在葡萄牙河流中的出现：检测到的基因中有 bla、bla 和 bla。
Environ Pollut. 2020 May;260:113913. doi: 10.1016/j.envpol.2020.113913. Epub 2020 Jan 6.
2
Characterization of NDM-1- and CMH-3-producing Enterobacter cloacae complex ST932 in a patient transferred from Ukraine to Spain.对一名从乌克兰转至西班牙的患者体内产NDM-1和CMH-3的阴沟肠杆菌复合体ST932的特征分析。
Enferm Infecc Microbiol Clin (Engl Ed). 2020 Aug-Sep;38(7):327-330. doi: 10.1016/j.eimc.2019.10.007. Epub 2019 Dec 6.
3
Population structure and pangenome analysis of Enterobacter bugandensis uncover the presence of bla, bla and bla, along with sophisticated iron acquisition strategies.肠杆菌属细菌的种群结构和泛基因组分析揭示了 bla、bla 和 bla 的存在，以及复杂的铁获取策略。
Genomics. 2020 Mar;112(2):1182-1191. doi: 10.1016/j.ygeno.2019.07.003. Epub 2019 Jul 4.
4
Multidrug-Resistant Complex Emerging as a Global, Diversifying Threat.多重耐药复合体正成为一种全球性、不断多样化的威胁。
Front Microbiol. 2019 Jan 31;10:44. doi: 10.3389/fmicb.2019.00044. eCollection 2019.
5
Multi-drug resistant Enterobacter bugandensis species isolated from the International Space Station and comparative genomic analyses with human pathogenic strains.从国际空间站分离的多药耐药阴沟肠杆菌种及其与人类致病性菌株的比较基因组分析。
BMC Microbiol. 2018 Nov 23;18(1):175. doi: 10.1186/s12866-018-1325-2.
6
subsp. subsp. nov., subsp. comb. nov., sp. nov., and is a later heterotypic synonym of based on computational analysis of sequenced genomes.亚种、新亚种、新组合亚种、新种，并且基于对已测序基因组的计算分析，是……的晚出异名。
F1000Res. 2018 May 1;7:521. doi: 10.12688/f1000research.14566.2. eCollection 2018.
7
Enterobacter sichuanensis sp. nov., recovered from human urine.四川肠杆菌新种，从人尿中分离得到。
Int J Syst Evol Microbiol. 2018 Dec;68(12):3922-3927. doi: 10.1099/ijsem.0.003089. Epub 2018 Nov 2.
8
Outbreak of IMI-1 carbapenemase-producing colistin-resistant Enterobacter cloacae on the French island of Mayotte (Indian Ocean).印度洋马约特岛爆发产 IMI-1 碳青霉烯酶多黏菌素耐药阴沟肠杆菌感染。
Int J Antimicrob Agents. 2018 Sep;52(3):416-420. doi: 10.1016/j.ijantimicag.2018.05.015. Epub 2018 May 26.
9
Enterobacter cloacae Complex Isolated from Shrimps from Vietnam Carrying Resistant to Carbapenems but Not Cephalosporins.从越南虾中分离出的阴沟肠杆菌复合体对碳青霉烯类耐药，但对头孢菌素类不耐药。
Antimicrob Agents Chemother. 2018 Jun 26;62(7). doi: 10.1128/AAC.00398-18. Print 2018 Jul.
10
Carbapenem-resistant Enterobacteriaceae in wildlife, food-producing, and companion animals: a systematic review.野生动物、食品生产动物和伴侣动物中的耐碳青霉烯肠杆菌科：系统评价。
Clin Microbiol Infect. 2018 Dec;24(12):1241-1250. doi: 10.1016/j.cmi.2018.04.004. Epub 2018 Apr 11.
Zotero 插件