一只成年雌性绿猴（草原绿猴）患哮喘
Asthma in an Adult Female Vervet Monkey (Chlorocebus sabaeus).
作者信息
Köster Liza S, Simon Bradley, Rawlins Gilda, Beierschmitt Amy
机构信息
Department of Clinical Sciences, Ross University School of Veterinary Medicine, St Kitts and Nevis, West Indies.
Department of Clinical Sciences, Ross University School of Veterinary Medicine, St Kitts and Nevis, West Indies; Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, USA.
出版信息
Comp Med. 2016 Feb;66(1):68-72.
A 9-y-old, colony-bred, female vervet monkey (Chlorocebus sabaeus) presented with a 6-y history of open-mouth breathing, tachypnea, and sibilant wheezing. These symptoms did not significantly affect her activity or quality of life. Thoracic radiographs and results of bronchoalveolar lavage supported the diagnosis of asthma. Treatment comprising intramuscular prednisolone (tapered over 2 mo from twice daily to every other day), inhaled salmeterol-fluticasone (25 μg-250 μg per actuation twice daily) by mask, and a metered dose inhaler was successful in restoring a normal respiratory pattern. Despite the availability of several primate models of human asthma, this case represents the first report of spontaneous asthma in a NHP.
一只9岁、圈养繁殖的雌性黑长尾猴（Chlorocebus sabaeus）出现了6年的张口呼吸、呼吸急促和高调哮鸣症状。这些症状并未显著影响其活动或生活质量。胸部X光片和支气管肺泡灌洗结果支持哮喘的诊断。治疗包括肌肉注射泼尼松龙（在2个月内从每日两次逐渐减量至隔日一次）、通过面罩吸入沙美特罗-氟替卡松（每次吸入25μg - 250μg，每日两次）以及使用定量吸入器，成功恢复了正常呼吸模式。尽管有几种人类哮喘的灵长类动物模型，但该病例是首次报道非人类灵长类动物自发性哮喘。
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