Gardhouse Sara M, Eshar David, Bello Nora, Mason Diane
J Am Vet Med Assoc. 2015 Aug 15;247(4):404-8. doi: 10.2460/javma.247.4.404.
To describe changes in venous blood gas analytes during isoflurane anesthesia in black-tailed prairie dogs (Cynomys ludovicianus).
Prospective study.
16 black-tailed prairie dogs.
Black-tailed prairie dogs were placed in an anesthesia chamber for induction of general anesthesia, which was maintained with isoflurane in oxygen delivered via mask. Immediately following anesthetic induction, a venous blood sample was obtained from the medial saphenous vein; a second venous blood sample was obtained just prior to anesthetic gas shutoff. An evaluation of venous blood gas analytes was performed on each sample. General linear mixed models with repeated measures were used for data analyses.
Median anesthetic time was 90 minutes (range, 60 to 111 minutes). A significant increase from immediately after induction to completion of anesthesia was observed in Pco2 and mean blood chloride ion, BUN, and creatinine concentrations. A decrease in Po2, mean blood pH, and anion gap was observed from induction of anesthesia to completion. No significant differences during anesthesia were observed in mean base excess or blood bicarbonate, sodium, potassium, calcium, magnesium, blood glucose, lactate, and total CO2 concentrations. No complications occurred during or after anesthesia for any animal.
Examination of prairie dogs often requires general anesthesia, with isoflurane currently the inhalation agent of choice. Results suggested respiratory acidosis and relative azotemia may occur during isoflurane anesthesia of prairie dogs. Given the increased risk associated with anesthesia in small mammals and the propensity for respiratory disease in prairie dogs, insight into physiologic changes associated with isoflurane anesthesia in healthy prairie dogs can aid in perioperative evaluation and anesthetic monitoring in this rodent species.
描述黑尾土拨鼠（草原犬鼠）在异氟烷麻醉期间静脉血气分析物的变化。
前瞻性研究。
16只黑尾土拨鼠。
将黑尾土拨鼠置于麻醉箱中诱导全身麻醉，通过面罩吸入异氟烷和氧气维持麻醉。麻醉诱导后立即从隐静脉采集静脉血样；在停止麻醉气体供应前采集第二份静脉血样。对每份血样进行静脉血气分析物评估。采用重复测量的一般线性混合模型进行数据分析。
中位麻醉时间为90分钟（范围60至111分钟）。从诱导麻醉后即刻至麻醉结束，观察到Pco2、平均血氯离子、血尿素氮和肌酐浓度显著升高。从麻醉诱导至结束，观察到Po2、平均血pH值和阴离子间隙降低。麻醉期间平均碱剩余、血碳酸氢根、钠、钾、钙、镁、血糖、乳酸和总CO2浓度无显著差异。所有动物在麻醉期间及麻醉后均未出现并发症。
对土拨鼠的检查通常需要全身麻醉，异氟烷目前是首选的吸入麻醉剂。结果表明，在对土拨鼠进行异氟烷麻醉期间可能会发生呼吸性酸中毒和相对性氮血症。鉴于小型哺乳动物麻醉相关风险增加以及土拨鼠易患呼吸道疾病，了解健康土拨鼠异氟烷麻醉相关的生理变化有助于对该啮齿动物进行围手术期评估和麻醉监测。
