一种用于筛查速发型呼吸道过敏状态的吸入性变应原特异性IgE新检测方法（Phadiatop）。

A new test for specific IgE to inhalant allergens (Phadiatop) in the screening of immediate respiratory hypersensitivity states.

作者信息

Matricardi P M, Fattorossi A, Nisini R, Le Moli S, Castagliuolo P P, D'Amelio R

机构信息

Department of Medicine, DASRS, Pratica di Mare, Italy.

出版信息

Ann Allergy. 1989 Dec;63(6 Pt 1):532-5.

PMID:2688492

Abstract

Three hundred recruits were classified as either allergic or nonallergic to inhalant allergens on the basis of history, physical examination, skin testing, and RAST. Forty-nine (16.3%) were classified as allergic as they were affected by oculorhinitis and/or asthma. This diagnosis was compared with results obtained with PRIST and with a new commercially available multi-RAST test for inhalant allergy, Phadiatop (Pharmacia). Sixty subjects (20%), including all 49 allergic subjects, scored positive in the Phadiatop assay (100% sensitivity) while PRIST (cut-off 220 IU/mL) identified only 20/49 allergics (40.8% sensitivity). The correlation between RAST and Phadiatop was excellent. Phadiatop is much more sensitive than PRIST; furthermore, Phadiatop is easier, less expensive, and as reliable as RAST for use in mass screening programs.

摘要

根据病史、体格检查、皮肤试验和放射变应原吸附试验（RAST），300名新兵被分为对吸入性变应原过敏或不过敏两类。49名（16.3%）因患眼鼻炎和/或哮喘而被归类为过敏。将这一诊断结果与用PRIST及一种新的市售吸入性过敏多RAST试验Phadiatop（法玛西亚公司）所获得的结果进行了比较。60名受试者（20%），包括所有49名过敏受试者，在Phadiatop试验中呈阳性（敏感性100%），而PRIST（临界值220 IU/mL）仅识别出49名过敏者中的20名（敏感性40.8%）。RAST与Phadiatop之间的相关性极佳。Phadiatop比PRIST敏感得多；此外，在大规模筛查项目中使用时，Phadiatop操作更简便、成本更低，且与RAST一样可靠。