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小脑共济失调作为甲状腺功能减退症的首发症状

Cerebellar ataxia as presenting feature of hypothyroidism.

作者信息

Kotwal Suman Kumar, Kotwal Shalija, Gupta Rohan, Singh Jang Bhadur, Mahajan Annil

机构信息

Department of Medicine, Government Medical College, Jammu, India.

Department of Pathology, Government Medical College, Jammu, India.

出版信息

Arch Endocrinol Metab. 2016 Apr;60(2):183-5. doi: 10.1590/2359-3997000000121. Epub 2016 Feb 16.

Abstract

Symptoms and signs of the hypothyroidism vary in relation to the magnitude and acuteness of the thyroid hormone deficiency. The usual clinical features are constipation, fatigue, cold intolerance and weight gain. Rarely it can present with neurologic problems like reversible cerebellar ataxia, dementia, peripheral neuropathy, psychosis and coma. Hypothyroidism should be suspected in all cases of ataxia, as it is easily treatable. A 40 year-old male presented with the history facial puffiness, hoarseness of voice and gait-ataxia. Investigations revealed frank primary hypothyroidism. Anti-TPO antibody was positive. Thyroxine was started and patient improved completely within eight weeks. Hypothyroidism can present with ataxia as presenting feature. Hypothyroidism should be considered in all cases of cerebellar ataxia as it is a reversible cause of ataxia.

摘要

甲状腺功能减退的症状和体征因甲状腺激素缺乏的程度和急性程度而异。常见的临床特征包括便秘、疲劳、不耐寒和体重增加。极少数情况下,它可表现为神经问题,如可逆性小脑共济失调、痴呆、周围神经病变、精神病和昏迷。所有共济失调病例均应怀疑甲状腺功能减退,因为其易于治疗。一名40岁男性,有面部肿胀、声音嘶哑和步态共济失调病史。检查显示为明显的原发性甲状腺功能减退。抗甲状腺过氧化物酶抗体呈阳性。开始给予甲状腺素治疗,患者在八周内完全康复。甲状腺功能减退可表现为共济失调作为首发特征。所有小脑共济失调病例均应考虑甲状腺功能减退,因为它是共济失调的一个可逆病因。

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