拉科酰胺治疗儿童难治性全身性癫痫的疗效和耐受性
Efficacy and Tolerability of Lacosamide in the Treatment of Children With Refractory Generalized Epilepsy.
作者信息
Miskin Chandrabhaga, Khurana Divya S, Valencia Ignacio, Legido Agustin, Hasbani Daphne M, Carvalho Karen S
机构信息
Department of Pediatrics, Section of Neurology, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USA.
Department of Pediatrics, Section of Neurology, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USA
出版信息
J Child Neurol. 2016 Jun;31(7):925-8. doi: 10.1177/0883073816630084. Epub 2016 Feb 16.
Lacosamide is FDA-approved in patients 17 years or older with partial-onset epilepsy. We evaluated the efficacy and tolerability of lacosamide in children with refractory generalized epilepsy. We retrospectively reviewed records of 21 children with refractory generalized epilepsy treated with lacosamide in our institution from 2009-2013 divided into 2 subgroups- I, Lennox-Gastaut Syndrome, and II, other generalized epilepsies. Efficacy was defined as seizure freedom or ≥50% seizure reduction. Descriptive data analysis including seizure freedom was compared using c(2) analysis. There were eleven females and ten males with a mean age, of 11.9 years. Five patients became seizure free, nine had ≥50% seizure reduction, and seven had no response. Group I: seven had ≥50% improvement, one did not respond. Group II: five became seizure free, two had ≥50% improvement, five had no response. Lacosamide is effective and well tolerated in children with refractory generalized epilepsy particularly patients with Lennox-Gastaut Syndrome.
拉科酰胺已获美国食品药品监督管理局（FDA）批准，用于治疗17岁及以上的部分性发作癫痫患者。我们评估了拉科酰胺在难治性全身性癫痫儿童中的疗效和耐受性。我们回顾性分析了2009年至2013年在我们机构接受拉科酰胺治疗的21例难治性全身性癫痫儿童的记录，这些儿童被分为两个亚组——I组，伦诺克斯-加斯东综合征，和II组，其他全身性癫痫。疗效定义为无癫痫发作或癫痫发作减少≥50%。使用卡方（c(2)）分析比较包括无癫痫发作在内的描述性数据分析。有11名女性和10名男性，平均年龄为11.9岁。5例患者无癫痫发作，9例癫痫发作减少≥50%，7例无反应。I组：7例改善≥50%，1例无反应。II组：5例无癫痫发作，2例改善≥50%，5例无反应。拉科酰胺在难治性全身性癫痫儿童中，尤其是伦诺克斯-加斯东综合征患者中，有效且耐受性良好。
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