Hernandez-Castillo Carlos R, Vaca-Palomares Israel, Galvez Víctor, Campos-Romo Aurelio, Diaz Rosalinda, Fernandez-Ruiz Juan
1Consejo Nacional de Ciencia y Tecnología - Cátedras - Instituto de Neuroetología,Universidad Veracruzana,México.
2Laboratorio de Neuropsicología,Departamento de Fisiología, Facultad de Medicina,Universidad Nacional Autónoma de México,México.
J Int Neuropsychol Soc. 2016 Apr;22(4):486-91. doi: 10.1017/S1355617716000084. Epub 2016 Feb 18.
The aim of this study was to explore the relationship between cognitive and white matter deterioration in a group of participants with spinocerebellar ataxia type 2 (SCA2).
Fourteen genetically confirmed participants with SCA2 and 14 aged-matched controls participated in the study. Diffusion tensor imaging tract-based spatial statistics were performed to analyze structural white matter integrity. Significant group differences in the mean diffusivity were correlated with SCA2 cognitive deficits.
Our analysis revealed higher mean diffusivity in the SCA2 group in cerebellar white matter, medial lemniscus, and middle cerebellar peduncle, among other regions. Cognitive scores correlated with white matter mean diffusivity in the parahippocampal area, inferior frontal and supramarginal gyri and the stria terminalis.
Our findings show significant correlations between white matter microstructural damage in key areas affected in SCA2 and cognitive deficits. These findings result in a more comprehensive understanding of the effect of the neurodegenerative process in people with SCA2.
本研究旨在探讨一组2型脊髓小脑共济失调（SCA2）患者认知功能与白质退化之间的关系。
14名经基因确诊的SCA2患者和14名年龄匹配的对照者参与了本研究。采用基于扩散张量成像的纤维束空间统计分析来评估白质结构完整性。平均扩散率的显著组间差异与SCA2认知缺陷相关。
我们的分析显示，SCA2组在小脑白质、内侧丘系和小脑中脚等区域的平均扩散率较高。认知评分与海马旁区域、额下回、缘上回及终纹床核的白质平均扩散率相关。
我们的研究结果表明，SCA2所累及的关键区域白质微观结构损伤与认知缺陷之间存在显著相关性。这些发现有助于更全面地理解神经退行性变过程对SCA2患者的影响。
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