Merli I P, Levenson J, Filitti V, Simon A
Diagnostic Center, Hôpital Broussais, Paris, France.
Clin Pharmacol Ther. 1989 Dec;46(6):686-92. doi: 10.1038/clpt.1989.205.
The long-term effects of selective (atenolol) and nonselective (carteolol) beta-blockers on brachial artery diameter velocity and flow and on vascular resistance (pulsed Doppler) were compared in two groups of 10 hypertensive patients at respective daily doses of 100 and 20 mg. The drugs decreased mean blood pressure (p less than 0.01) with similar magnitude, although systolic blood pressure was decreased more by atenolol than by carteolol (p less than 0.05). Heart rate was decreased by atenolol (p less than 0.01) but was unchanged by carteolol. The drugs did not change brachial circulation when the hand circulation was present. During hand exclusion (wrist occlusion) comparison from baseline showed that atenolol decreased velocity and flow (p less than 0.01, p less than 0.05) and increased resistance (p less than 0.05), whereas carteolol decreased resistance (p less than 0.05); after 3 months of treatment, velocity and flow were higher (p less than 0.01, p less than 0.001) and resistance was lower (p less than 0.01) with carteolol than with atenolol. Thus, hand exclusion demonstrated opposite drug effects on arterioles--dilation for carteolol and constriction for atenolol.
在两组各10名高血压患者中，分别以每日100毫克和20毫克的剂量比较了选择性β受体阻滞剂（阿替洛尔）和非选择性β受体阻滞剂（卡替洛尔）对肱动脉直径、流速、血流量及血管阻力（脉冲多普勒）的长期影响。两种药物降低平均血压的幅度相似（p<0.01），尽管阿替洛尔降低收缩压的幅度大于卡替洛尔（p<0.05）。阿替洛尔使心率降低（p<0.01），而卡替洛尔对心率无影响。当手部血液循环存在时，两种药物对肱动脉循环无影响。在手部血液循环阻断（手腕阻断）期间，与基线相比，阿替洛尔使流速和血流量降低（p<0.01，p<0.05），阻力增加（p<0.05），而卡替洛尔使阻力降低（p<0.05）；治疗3个月后，卡替洛尔组的流速和血流量高于阿替洛尔组（p<0.01，p<0.001），阻力低于阿替洛尔组（p<0.01）。因此，手部血液循环阻断显示了两种药物对小动脉的相反作用——卡替洛尔使小动脉扩张，阿替洛尔使小动脉收缩。
