X-ray propagation-based equally sloped tomography for mouse brain.
作者信息
Ren Yuqi, Wang Yudan, Zhou Guangzhao, He You, Xie Honglan, Du Guohao, Deng Biao, Lin Xiaojie, Yang Guo-Yuan, Xiao Tiqiao
机构信息
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.
出版信息
J Xray Sci Technol. 2016;24(1):79-86. doi: 10.3233/XST-160533.
BACKGROUND
The outstanding functional importance of the brain implies a strong need for brain imaging modalities. However, the current imaging approaches that target the brain in rodents remain suboptimal.
OBJECTIVE AND METHODS
In this paper, X-ray propagation-based phase contrast imaging combined with equally sloped tomography (PPCI-EST) was employed to nondestructively investigate the mouse brain.
RESULTS
The grey and white matters, which have extremely small differences in electron density, were clearly discriminated. The fine structures, including the corpus callosum (cc), the optic chiasma (ox) and the caudate putamen (CPu), were revealed. Compared to the filtered back projection reconstruction, the PPCI-EST significantly reduce projection number while maintaining sufficient image quality.
CONCLUSIONS
It could be a potential tool for fast and low-dose phase-contrast imaging to biomedical specimens.
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