脾五肽在全身照射后诱导免疫反应重建：治疗方案的优化
Splenopentin-induced reconstitution of the immune response after total body irradiation: optimization of treatment regime.
作者信息
Eckert R, Schmidt R, Volk H D, Diezel W, Sönnichsen N, von Baehr R
机构信息
Institute of Medical Immunology, Medical School (Charité), Humboldt University, Berlin, GDR.
出版信息
Exp Clin Endocrinol. 1989 Sep;94(1-2):223-5. doi: 10.1055/s-0029-1210902.
In former investigations our group obtained an immuno-reconstituting effect in mice treated by immunosuppression after a continuous treatment with splenopentin (SP5). The goal of the present study was to test whether a small number of injections right after immunosuppression possibly produces the same result in the sense of an initial effect. Although a short-term therapy induced an increase of antibody formation which was measurable after 4 weeks, the study clearly showed that only a continuous treatment by SP5 led to an optimum, i.e. complete reconstitution of antibody formation.
在之前的研究中，我们的团队在连续使用脾五肽（SP5）治疗后对免疫抑制小鼠进行治疗，获得了免疫重建效果。本研究的目的是测试在免疫抑制后立即进行少量注射是否可能在初始效应方面产生相同的结果。尽管短期治疗诱导了抗体形成的增加，在4周后可以检测到，但该研究清楚地表明，只有通过SP5进行连续治疗才能导致最佳效果，即抗体形成的完全重建。
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