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脂类与减重手术:第 1 部分(共 2 部分):来自国家脂类协会、美国代谢与减重外科学会和肥胖医学协会的科学声明:执行摘要。

Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: EXECUTIVE SUMMARY.

机构信息

Louisville Metabolic and Atherosclerosis Research Center (L-MARC), Louisville, KY, USA.

Methodist DeBakey Heart and Vascular Center, Baylor College of Medicine, Houston, TX, USA.

出版信息

J Clin Lipidol. 2016 Jan-Feb;10(1):15-32. doi: 10.1016/j.jacl.2015.12.003. Epub 2015 Dec 22.

Abstract

Bariatric procedures often improve lipid levels in patients with obesity. This 2-part scientific statement examines the potential lipid benefits of bariatric procedures and represents contributions from authors representing the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and the Obesity Medicine Association. The foundation for this scientific statement was based on data published through June 2015. Part 1 of this 2-part scientific statement provides an overview of: (1) adipose tissue, cholesterol metabolism, and lipids; (2) bariatric procedures, cholesterol metabolism, and lipids; (3) endocrine factors relevant to lipid influx, synthesis, metabolism, and efflux; (4) immune factors relevant to lipid influx, synthesis, metabolism, and efflux; (5) bariatric procedures, bile acid metabolism, and lipids; and (6) bariatric procedures, intestinal microbiota, and lipids, with specific emphasis on how the alterations in the microbiome by bariatric procedures influence obesity, bile acids, and inflammation, which in turn, may all affect lipid levels. Included in part 2 of this comprehensive scientific statement will be a review of: (1) the importance of nutrients (fats, carbohydrates, and proteins) and their absorption on lipid levels; (2) the effects of bariatric procedures on gut hormones and lipid levels; (3) the effects of bariatric procedures on nonlipid cardiovascular disease risk factors; (4) the effects of bariatric procedures on lipid levels; (5) effects of bariatric procedures on cardiovascular disease; and finally (6) the potential lipid effects of vitamin, mineral, and trace element deficiencies that may occur after bariatric procedures. This document represents the executive summary of part 1.

摘要

减重手术通常可改善肥胖患者的血脂水平。本科学声明共分为两部分,旨在探讨减重手术对血脂的潜在益处,由美国国家脂质协会、美国代谢与减重外科学会和肥胖医学协会的专家共同撰写。本科学声明的基础数据截止至 2015 年 6 月。本声明的第一部分概述了以下内容:(1)脂肪组织、胆固醇代谢与血脂;(2)减重手术、胆固醇代谢与血脂;(3)与脂质内流、合成、代谢和外排相关的内分泌因素;(4)与脂质内流、合成、代谢和外排相关的免疫因素;(5)减重手术、胆汁酸代谢与血脂;(6)减重手术、肠道微生物群与血脂,特别强调了减重手术对肠道微生物组的改变如何影响肥胖、胆汁酸和炎症,而这些因素反过来又可能影响血脂水平。本科学声明的第二部分将对以下内容进行全面审查:(1)营养物质(脂肪、碳水化合物和蛋白质)及其对血脂水平的吸收的重要性;(2)减重手术对肠道激素和血脂水平的影响;(3)减重手术对非脂性心血管疾病风险因素的影响;(4)减重手术对血脂水平的影响;(5)减重手术对心血管疾病的影响;最后(6)减重手术后可能出现的维生素、矿物质和微量元素缺乏对血脂的潜在影响。本文是第一部分的执行摘要。

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