Akbari Mohsen, Goodarzi Nader, Tavafi Majid
Department of Basic Science, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Department of Anatomy, Faculty of Medicine, Lorestan University of Medical Sciences, Khoram Abad, Iran.
Anat Sci Int. 2017 Mar;92(2):267-274. doi: 10.1007/s12565-016-0332-3. Epub 2016 Feb 19.
The functions of the mammalian kidney are closely related to its structure. This suggests that renal function can be completely characterized by accurate knowledge of its quantitative morphological features. The aim of this study was to investigate the histomorphometric features of the kidney using design-based and unbiased stereological methods in the Persian squirrel (Sciurus anomalus), which is the only representative of the Sciuridae family in the Middle East. The left kidneys of five animals were examined. Total volume of the kidney, cortex, and medulla were determined to be 960.75 ± 87.4, 754.31 ± 77.09 and 206.1 ± 16.89 mm, respectively. The glomerular number was 32844.03 ± 1069.19, and the total glomerular volume was estimated to be 36.7 ± 1.45 mm. The volume and length of the proximal convoluted tubule were estimated at 585.67 ± 60.7 mm and 328.8 ± 14.8 m, respectively, with both values being greater than those reported in the rat kidney. The volume and length of the distal convoluted tubule were calculated at 122.34 ± 7.38 mm and 234.4 ± 17.45 m, respectively, which are also greater than those reported in the rat kidney. Despite the comparable body weight, the total number and mean individual volume of glomeruli in the Persian squirrel kidney were greater than those in the rat kidney. Overall, the stereological variables of the kidneys elucidated in this study are exclusive to the Persian squirrel. Our findings, together with future renal physiological data, will contribute to a better understanding of the renal structure-function relationship in the Persian squirrel.
哺乳动物肾脏的功能与其结构密切相关。这表明，通过准确了解其定量形态特征，肾功能可以得到全面表征。本研究的目的是使用基于设计的无偏体视学方法，研究中东地区松鼠科唯一代表物种波斯松鼠（Sciurus anomalus）的肾脏组织形态计量学特征。对五只动物的左肾进行了检查。肾脏、皮质和髓质的总体积分别确定为960.75±87.4、754.31±77.09和206.1±16.89立方毫米。肾小球数量为32844.03±1069.19，肾小球总体积估计为36.7±1.45立方毫米。近端曲管的体积和长度估计分别为585.67±60.7立方毫米和328.8±14.8米，两者均大于大鼠肾脏中的报道值。远端曲管的体积和长度分别计算为122.34±7.38立方毫米和234.4±17.45米，也大于大鼠肾脏中的报道值。尽管体重相当，但波斯松鼠肾脏中肾小球的总数和平均个体体积均大于大鼠肾脏。总体而言，本研究阐明的肾脏体视学变量是波斯松鼠所特有的。我们的研究结果，连同未来的肾脏生理学数据，将有助于更好地理解波斯松鼠的肾脏结构-功能关系。
