内镜下球囊扩张治疗结直肠吻合口狭窄的长期疗效
Long-term results of endoscopic balloon dilation for treatment of colorectal anastomotic stenosis.
作者信息
Biraima Magdalena, Adamina Michel, Jost Res, Breitenstein Stefan, Soll Christopher
机构信息
Department of Visceral and Thoracic Surgery, Cantonal Hospital Winterthur, Brauerstrasse 15, 8401, Winterthur, Switzerland.
Department of Gastroenterology and Hepatology, Cantonal Hospital Winterthur, Winterthur, Switzerland.
出版信息
Surg Endosc. 2016 Oct;30(10):4432-7. doi: 10.1007/s00464-016-4762-8. Epub 2016 Feb 19.
BACKGROUND
Despite standardized techniques, anastomotic complications after colorectal resection remain a challenging problem. Among those, anastomotic stricture is a debilitating outcome which often requires multiple interventions and which is prone to recur. The present series investigates the long-term results of endoscopic balloon dilation for stenotic colorectal anastomosis.
METHODS
Consecutive patients from a single institution who presented with an anastomotic stenosis after a colorectal resection were identified using a prospective clinical database. Medical records were systematically reviewed to detail patients' outcomes.
RESULTS
Over 17 years (1988-2015), 2361 consecutive patients underwent a colorectal anastomosis. Of those, 76 patients (3.2 %) suffered a symptomatic anastomotic stenosis within a median of 5 months (interquartile range (IQR) 2-13) of the index procedure. All stenoses were primarily treated by endoscopic balloon dilation. Median follow-up was 11 years (IQR 7-14). In half the patients, one to two attempts at endoscopic balloon dilation definitively relieved the stenosis. Overall, the median number of endoscopic balloon dilation required was 3 (IQR 2-3). Recurrence rates at 1 year, 3 year, and 5 year were 11, 22, and 25 %, respectively. Median time to recurrence was 12 months (IQR 3-24). Ultimately, two patients (2.6 %) underwent an operation due to failure of endoscopic treatment. All other patients (97.4 %) were treated successfully with endoscopic balloon dilation. A total of 12 patients (15.7 %) suffered a complication from endoscopic dilation. Of those, 11 were minor bleeding and one was a perforation at the level of the anastomosis. All complications were managed conservatively, and no emergency procedure was required as a consequence of attempted endoscopic balloon dilation.
CONCLUSION
Endoscopic balloon dilation is a safe approach to effectively relieve an anastomotic stenosis following a colorectal resection.
背景
尽管采用了标准化技术,但结直肠切除术后的吻合口并发症仍然是一个具有挑战性的问题。其中,吻合口狭窄是一种使人衰弱的结果,常常需要多次干预且易于复发。本系列研究探讨了内镜下球囊扩张治疗结直肠吻合口狭窄的长期效果。
方法
利用前瞻性临床数据库,从单一机构中确定连续出现结直肠切除术后吻合口狭窄的患者。系统回顾病历以详细了解患者的预后情况。
结果
在17年(1988 - 2015年)期间,2361例连续患者接受了结直肠吻合术。其中,76例患者(3.2%)在初次手术的中位时间5个月(四分位间距(IQR)2 - 13)内出现有症状的吻合口狭窄。所有狭窄均首先通过内镜下球囊扩张进行治疗。中位随访时间为11年(IQR 7 - 14)。一半的患者经一至两次内镜下球囊扩张尝试后狭窄得到明确缓解。总体而言,所需内镜下球囊扩张的中位次数为3次(IQR 2 - 3)。1年、3年和5年的复发率分别为11%、22%和25%。复发的中位时间为12个月(IQR 3 - 24)。最终有2例患者(2.6%)因内镜治疗失败而接受手术。所有其他患者(97.4%)通过内镜下球囊扩张治疗成功。共有12例患者(15.7%)出现内镜扩张并发症。其中,11例为轻微出血,1例为吻合口处穿孔。所有并发症均经保守处理,内镜下球囊扩张尝试未导致需要进行急诊手术。
结论
内镜下球囊扩张是有效缓解结直肠切除术后吻合口狭窄的一种安全方法。