Bodwell W
J Cardiovasc Nurs. 1989 Nov;4(1):25-32. doi: 10.1097/00005082-198911000-00005.
Pathologic cellular changes that begin with ischemia may be worsened when an occluded artery is recannulized. Thrombolytic agents--the standard treatment in acute MI--may contribute to these cellular events, collectively termed "reperfusion injury." Highly toxic chemical moieties called oxygen free radicals participate in the injury process. This article discusses the concepts of ischemia, reperfusion, and reperfusion injury and explains the role played by oxygen free radicals in the generation of reperfusion injury. Also described is the use of oxygen free radical scavengers to prevent this injury.
始于局部缺血的病理性细胞变化，在闭塞动脉再通时可能会恶化。溶栓剂——急性心肌梗死的标准治疗方法——可能会导致这些细胞事件，统称为“再灌注损伤”。被称为氧自由基的剧毒化学基团参与了损伤过程。本文讨论了局部缺血、再灌注和再灌注损伤的概念，并解释了氧自由基在再灌注损伤发生过程中所起的作用。还介绍了使用氧自由基清除剂来预防这种损伤的方法。
