肿瘤抑制候选基因1抑制胶质母细胞瘤细胞生长并预示更好的生存预后
Tumor Suppressor Candidate 1 Suppresses Cell Growth and Predicts Better Survival in Glioblastoma.
作者信息
Zhang Rui, Yu Wan, Liang Guanyu, Jia Zhanjun, Chen Zhengxin, Zhao Lin, Yuan Yongsheng, Zhou Xiaobin, Li Daqian, Shen Shuying, Liu Ning, Zhang Aihua, Wang Huibo, Wang Gang
机构信息
Department of Neurosurgery, Nanjing Children's Hospital, Affiliated to Nanjing Medical University, Nanjing, 210029, China.
Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
出版信息
Cell Mol Neurobiol. 2017 Jan;37(1):37-42. doi: 10.1007/s10571-016-0339-2. Epub 2016 Feb 20.
Glioblastoma (GBM) is the most common malignant brain tumor with poor prognosis and limited treatment options. Tumor suppressor candidate 1 (TUSC1) was recently identified as a potential tumor suppressor in human cancers. However, the expression and potential function of TUSC1 in GBM remain unclear. Herein, we report that TUSC1 is significantly decreased in GBM tissues and cell lines. Patients with high levels of TUSC1 displayed a significant better survival compared with those with low levels of TUSC1. Functional experiments demonstrated that exogenous expression of TUSC1 inhibited GBM cell proliferation and induced G1 phase arrest by down-regulating CDK4. Moreover, overexpression of TUSC1 retarded tumor growth in vivo. Together, our findings revealed that TUSC1 might be a crucial tumor suppressor gene and a novel therapeutic target for GBM.
胶质母细胞瘤（GBM）是最常见的恶性脑肿瘤，预后较差且治疗选择有限。肿瘤抑制候选基因1（TUSC1）最近被确定为人类癌症中的一种潜在肿瘤抑制基因。然而，TUSC1在GBM中的表达和潜在功能仍不清楚。在此，我们报告TUSC1在GBM组织和细胞系中显著降低。与TUSC1水平低的患者相比，TUSC1水平高的患者生存情况明显更好。功能实验表明，TUSC1的外源性表达通过下调CDK4抑制GBM细胞增殖并诱导G1期阻滞。此外，TUSC1的过表达在体内延缓了肿瘤生长。总之，我们的研究结果表明TUSC1可能是一个关键的肿瘤抑制基因，也是GBM的一个新的治疗靶点。
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