Massagué Joan
Cancer Biology and Genetics Program, and Howard Hughes Medical Institute, Box 116, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York 10021, USA.
Nature. 2004 Nov 18;432(7015):298-306. doi: 10.1038/nature03094.
Before replicating DNA during their reproductive cycle, our cells enter a phase called G1 during which they interpret a flood of signals that influence cell division and cell fate. Mistakes in this process lead to cancer. An increasingly complex and coherent view of G1 signalling networks, which coordinate cell growth, proliferation, stress management and survival, is helping to define the roots of malignancies and shows promise for the development of better cancer therapies.
在细胞进行复制性繁殖周期时，我们的细胞会进入一个名为G1的阶段，在此期间，它们会解读大量影响细胞分裂和细胞命运的信号。这一过程中的错误会导致癌症。对G1信号网络日益复杂且连贯的认识，该网络协调细胞生长、增殖、应激管理和存活，有助于明确恶性肿瘤的根源，并为开发更好的癌症治疗方法带来希望。
