Nagorcka B N
CSIRO, Division of Entomology, Canberra ACT, Australia.
J Theor Biol. 1989 Mar 21;137(2):127-62. doi: 10.1016/s0022-5193(89)80202-4.
The patterns generated by these mechanisms are usually wavelike spatial patterns in the distribution of the chemical components and/or physical properties of the organism or tissue being considered. In this paper the range of patterns generated by one of these mechanisms, namely the reaction-diffusion (RD) system (Turing, 1952), is reviewed and its potential to function as a source of isomorphic prepatterns for the regulation of development in a wide range of organisms is illustrated. Examples have been chosen to show the capacity of an RD system to generate a single stationary spatial prepattern, as well as a travelling wavelike spatial prepattern. However, the full potential of an RD system to regulate development stems from its capacity to spontaneously generate a temporal sequence of isomorphic stationary wavelike spatial prepatterns, rather than just a single isomorphic stationary spatial prepattern. To demonstrate this point the examples presented include the morphogenesis of the skin and some of its appendages, as well as the early decisions in the embryogenesis of Drosophila leading to segmentation. The mini-review begins by comparing the concepts of positional information and a temporal sequence of isomorphic prepatterns, which represent two quite different approaches to understanding the spatial and temporal regulation of cellular differentiation.
这些机制所产生的模式通常是所研究的生物体或组织的化学成分和/或物理特性分布中的波状空间模式。本文回顾了其中一种机制——反应扩散（RD）系统（图灵，1952年）所产生的模式范围，并阐述了其作为多种生物体发育调控同构预模式来源的潜力。已选取实例来说明反应扩散系统产生单一静态空间预模式以及行进波状空间预模式的能力。然而，反应扩散系统调控发育的全部潜力源于其自发产生同构静态波状空间预模式时间序列的能力，而非仅仅是单个同构静态空间预模式。为证明这一点，所举实例包括皮肤及其一些附属器官的形态发生，以及果蝇胚胎发育中导致体节形成的早期决定。本小型综述首先比较了位置信息和同构预模式时间序列的概念，这代表了理解细胞分化时空调控的两种截然不同的方法。
