Dua Sumeet G, Jhaveri Miral D
Section of Neuroradiology, Department of Radiology, Rush University Medical Center, Chicago, IL 60612, USA.
Section of Neuroradiology, Department of Radiology, Rush University Medical Center, Chicago, IL 60612, USA.
J Clin Neurosci. 2016 Jul;29:205-6. doi: 10.1016/j.jocn.2015.12.014. Epub 2016 Feb 16.
Nelarabine is one of the newer and novel drugs approved by the USA Food and Drug Administration for treatment of relapsed and resistant acute lymphoblastic leukemia. Although there are a few accounts of the neurologic toxicity of nelarabine in the oncological literature, it has never been discussed from a radiologic stand point to our knowledge. We describe a case of nelarabine-induced myelopathy and review the existing literature in an attempt to characterize the MRI features helpful in making an early diagnosis of this elusive entity.
奈拉滨是美国食品药品监督管理局批准用于治疗复发和难治性急性淋巴细胞白血病的较新的新型药物之一。尽管肿瘤学文献中有一些关于奈拉滨神经毒性的报道，但据我们所知，从未从放射学角度进行过讨论。我们描述了一例奈拉滨诱导的脊髓病病例，并回顾现有文献，试图明确有助于早期诊断这一隐匿病症的MRI特征。
