UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N, 1AX, UK.
School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Adv Healthc Mater. 2016 Apr 20;5(8):977-85. doi: 10.1002/adhm.201500872. Epub 2016 Feb 22.
Magnetic resonance imaging is a diagnostic tool used for detecting abnormal organs and tissues, often using Gd(III) complexes as contrast-enhancing agents. In this work, core-shell polymer fibers have been prepared using coaxial electrospinning, with the intent of delivering gadolinium (III) diethylenetriaminepentaacetate hydrate (Gd(DTPA)) selectively to the colon. The fibers comprise a poly(ethylene oxide) (PEO) core loaded with Gd(DTPA), and a Eudragit S100 shell. They are homogeneous, with distinct core-shell phases. The components in the fibers are dispersed in an amorphous fashion. The proton relaxivities of Gd(DTPA) are preserved after electrospinning. To permit easy visualization of the release of the active ingredient from the fibers, analogous materials are prepared loaded with the dye rhodamine B. Very little release is seen in a pH 1.0 buffer, while sustained release is seen at pH 7.4. The fibers thus have the potential to selectively deliver Gd(DTPA) to the colon. Mucoadhesion studies reveal there are strong adhesive forces between porcine colon mucosa and PEO from the core, and the dye-loaded fibers can be successfully used to image the porcine colon wall. The electrospun core-shell fibers prepared in this work can thus be developed as advanced functional materials for effective imaging of colonic abnormalities.
磁共振成像是一种用于检测异常器官和组织的诊断工具，通常使用 Gd(III) 配合物作为对比增强剂。在这项工作中，使用同轴静电纺丝制备了核壳聚合物纤维，旨在将钆（III）二乙三胺五乙酸水合物（Gd(DTPA)）选择性递送到结肠。纤维由负载 Gd(DTPA)的聚氧化乙烯（PEO）核和 Eudragit S100 壳组成。它们是均匀的，具有明显的核壳相。纤维中的成分以无定形的方式分散。静电纺丝后，Gd(DTPA)的质子弛豫率得以保留。为了便于可视化观察纤维中活性成分的释放，类似的材料被制备并负载有染料罗丹明 B。在 pH 1.0 缓冲液中几乎观察不到释放，而在 pH 7.4 时则观察到持续释放。因此，这些纤维有可能将 Gd(DTPA)选择性递送到结肠。黏膜黏附研究表明，猪结肠黏膜和核心中的 PEO 之间存在很强的黏附力，负载染料的纤维可成功用于猪结肠壁成像。因此，本工作中制备的静电纺核壳纤维可以开发为用于有效成像结肠异常的先进功能材料。
