Nyerges G, Mészner Z
Orv Hetil. 1989 Dec 3;130(49):2615-20.
Data of 1208 infants and children hospitalized for purulent meningitis were analysed. The incidence of the disease was closely age related: morbidity calculated for 100,000 children was found 97.5 under one year of age; 15.6 in 1 to 5 and 2.2 in 6 to 14 years of age. Incidence of newborn meningitis cases was 3.7 per 10,000 live-borns. The disease was caused by N. meningitidis in 278 (23%), H. influenzae in 171 (14%), S. pneumoniae in 157 (13%), E. coli in 74 (6%), B-group streptococcus in 61 (5%), other bacteria (altogether 17 species) in 107 (9%) cases, while in 360 cases (30%) the etiology remained unknown. Overall case fatality was 19.6 per cent. When compared to international data mortality was especially high among the newborns (53%) and in meningitis cases due to S. pneumoniae (29%), E. coli (48%), B-group streptococcus (37%) and "other bacteria" (41%). Neurologic sequelae were found in 17 per cent of the patients at discharge however, in newborns it was 54 per cent. Since the antibacterial therapy was appropriate in all cases, authors try to reveal the possible causes of the relatively high mortality and make recommendations for reducing it.
对1208例因化脓性脑膜炎住院的婴幼儿和儿童的数据进行了分析。该疾病的发病率与年龄密切相关:每10万名儿童中,1岁以下的发病率为97.5;1至5岁为15.6;6至14岁为2.2。新生儿脑膜炎病例的发病率为每10000例活产儿3.7例。该疾病由脑膜炎奈瑟菌引起的有278例(23%),流感嗜血杆菌引起的有171例(14%),肺炎链球菌引起的有157例(13%),大肠杆菌引起的有74例(6%),B组链球菌引起的有61例(5%),其他细菌(共17种)引起的有107例(9%),而360例(30%)病例的病因仍不明。总体病死率为19.6%。与国际数据相比,新生儿(53%)以及由肺炎链球菌(29%)、大肠杆菌(48%)、B组链球菌(37%)和“其他细菌”(41%)引起的脑膜炎病例的死亡率尤其高。出院时,17%的患者有神经后遗症,然而新生儿的这一比例为54%。由于所有病例的抗菌治疗都是恰当的,作者试图揭示死亡率相对较高的可能原因并提出降低死亡率的建议。