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一名患有t(8;16)(p11;p13)先天性急性髓系白血病的长期存活者。

A Long-term Survivor after Congenital Acute Myeloid Leukemia with t(8 ; 16)(p11 ; p13).

作者信息

Hanada Takae, Kanamitsu Kiichiro, Chayama Kosuke, Miyamura Takako, Kanazawa Yui, Muraoka Michiko, Washio Kana, Imada Masahide, Kageyama Misao, Takeuchi Akihito, Tamai Kei, Oda Megumi, Shimada Akira

机构信息

Department of Pediatrics, Okayama University Hospital, Okayama 700-8558, Japan.

出版信息

Acta Med Okayama. 2016;70(1):31-5. doi: 10.18926/AMO/54001.

Abstract

The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8 ; 16) (p11 ; p13) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ-CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ-CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ-CBP in the pediatric population might show better prognoses.

摘要

先天性白血病患者的治疗困难,且往往预后不良。我们在此报告一例患有先天性急性髓系白血病(AML)伴t(8;16)(p11;p13)的女童,她接受了化疗,存活超过10年且未复发。在其诊断样本中发现了一种新的MOZ-CBP嵌合体。尽管主要报道的伴有MOZ-CBP的成人AML患者患有治疗相关AML且预后不良,但本病例支持了小儿AML伴有MOZ-CBP可能预后较好的观点。

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