Kulkarni Sameer S, Cantó Carles
Nestlé Institute of Health Sciences, Lausanne, CH-1015, Switzerland.
Nestlé Institute of Health Sciences S.A. EPFL Innovation Park, Building G, CH-1015, Lausanne, Switzerland.
Curr Diabetes Rev. 2017;13(4):338-351. doi: 10.2174/1573399812666160217122413.
In order to maintain metabolic homeostasis, organisms adjust the capacity and efficiency of ATP generation to changes in energetic demand and supply. While the transcriptional control of mitochondrial biogenesis allows to adapt mitochondrial respiratory capacity with long-term requirements for differential energy demand (e.g.: exercise training), bioenergetic adaptation also needs to take place within shorter time frames in order to properly fine-tune nutrient availability, energy production and demand, either in a circadian fashion or after a meal. These quick metabolic responses can be achieved through exquisite modulation of diverse post-translational modifications, which influence a variety of mitochondrial processes, including mitochondrial dynamics, fatty acid oxidation, lipogenesis and bioenergetic efficiency.
In this review, we will specially focus on the role of mitochondrial sirtuin enzymes as modulators of mitochondrial ac(et)ylation and the possible interactions with other posttranslational modification events.
为了维持代谢稳态，生物体根据能量需求和供应的变化来调整ATP生成的能力和效率。虽然线粒体生物发生的转录控制能够使线粒体呼吸能力适应长期不同能量需求（如运动训练），但生物能量适应也需要在较短时间内发生，以便以昼夜节律方式或餐后对营养物质可用性、能量产生和需求进行适当微调。这些快速的代谢反应可通过对各种翻译后修饰的精细调节来实现，这些修饰会影响多种线粒体过程，包括线粒体动力学、脂肪酸氧化、脂肪生成和生物能量效率。
在本综述中，我们将特别关注线粒体去乙酰化酶作为线粒体乙酰化调节剂的作用以及与其他翻译后修饰事件的可能相互作用。
