Goshima Satoshi, Kanematsu Masayuki, Noda Yoshifumi, Kawai Nobuyuki, Kawada Hiroshi, Ono Hiromi, Bae Kyongtae T
1 Department of Radiology, Gifu University Hospital, 1-1 Yanagido, 501-1194 Gifu, Japan.
2 Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA.
AJR Am J Roentgenol. 2016 Mar;206(3):518-25. doi: 10.2214/AJR.15.15138.
The objective of our study was to determine the iodine dose per unit of body weight (BW) or body surface area (BSA) that is minimally required to detect hypervascular hepatocellular carcinoma (HCC) on 80-kVp CT.
One hundred eleven patients (78 men and 33 women; mean age, 68 years; age range, 43-85 years) with chronic hepatitis were randomized into three groups with different iodine loads (0.5, 0.4, and 0.3 g I/kg BW) and underwent contrast-enhanced CT at 80 kVp. Enhancement of the liver and of hypervascular HCCs was quantitatively and qualitatively assessed on hepatic arterial, portal venous, and equilibrium phase images and compared between the groups. Values for iodine dose per unit of BSA (g I/m(2)) were also computed and analyzed.
No significant differences in the contrast-to-noise ratio (CNR) of hypervascular HCCs in any phase were found between the groups (p = 0.34-0.99). In the portal venous phase, the mean increase in hepatic contrast enhancement (ΔHU) of the 0.5 g I/kg group (80.3 HU) was higher than those of the 0.4 g I/kg (63.4 HU) and 0.3 g I/kg (53.3 HU) groups (p < 0.001). Linear correlation equations for the increase in hepatic contrast enhancement were as follows: ΔHU = 5.9 + 150.0 × IL(BW) (r = 0.69, p < 0.001), where IL(BW) is the iodine load per unit of BW (g I/kg), and ΔHU = 13.0 + 3.68 × IL(BSA) (r = 0.66, p < 0.001), where IL(BSA) is the iodine load pre unit of BSA (g I/m(2)).
The minimal iodine dose required to achieve a tumor-to-liver CNR that is acceptable for the detection of hypervascular HCCs on 80-kVp CT was 0.3 g I/kg BW or 11.0 g I/m(2) BSA.
我们研究的目的是确定在80 kVp CT上检测富血供肝细胞癌（HCC）所需的每单位体重（BW）或体表面积（BSA）的碘剂量。
111例慢性肝炎患者（78例男性，33例女性；平均年龄68岁；年龄范围43 - 85岁）被随机分为三组，给予不同的碘负荷量（0.5、0.4和0.3 g碘/千克体重），并在80 kVp下进行对比增强CT检查。在肝动脉期、门静脉期和平衡期图像上对肝脏和富血供HCC的强化进行定量和定性评估，并在组间进行比较。还计算并分析了每单位BSA的碘剂量值（克碘/平方米）。
组间在任何时期富血供HCC的对比噪声比（CNR）均无显著差异（p = 0.34 - 0.99）。在门静脉期，0.5 g碘/千克组肝脏对比增强的平均增加值（ΔHU）（80.3 HU）高于0.4 g碘/千克组（63.4 HU）和0.3 g碘/千克组（53.3 HU）（p < 0.001）。肝脏对比增强增加值的线性相关方程如下：ΔHU = 5.9 + 150.0 × IL（BW）（r = 0.69，p < 0.001），其中IL（BW）是每单位BW的碘负荷量（克碘/千克）；以及ΔHU = 13.0 + 3.68 × IL（BSA）（r = 0.66，p < 0.001），其中IL（BSA）是每单位BSA的碘负荷量（克碘/平方米）。
在80 kVp CT上检测富血供HCC时，实现可接受的肿瘤与肝脏CNR所需的最小碘剂量为0.3 g碘/千克体重或11.0 g碘/平方米BSA。
