Contera S
Oxford Martin Programme on Nanotechnology, Clarendon Laboratory, Physics Department, University of Oxford, Parks Road, Oxford, OX1 3PU, UK.
Nanotechnology. 2016 Apr 1;27(13):132501. doi: 10.1088/0957-4484/27/13/132501. Epub 2016 Feb 22.
Multifrequency excitation/monitoring of cantilevers has made it possible both to achieve fast, relatively simple, nanometre-resolution quantitative mapping of mechanical of biological systems in solution using atomic force microscopy (AFM), and single molecule resolution detection by nanomechanical biosensors. A recent paper by Penedo et al [2015 Nanotechnology 26 485706] has made a significant contribution by developing simple methods to improve the signal to noise ratio in liquid environments, by selectively enhancing cantilever modes, which will lead to even more accurate quantitative measurements.
对悬臂梁进行多频率激发/监测，使得利用原子力显微镜（AFM）在溶液中对生物系统的力学性质实现快速、相对简单的纳米级分辨率定量映射以及通过纳米机械生物传感器进行单分子分辨率检测成为可能。佩内多等人[《纳米技术》2015年第26卷，485706]最近发表的一篇论文做出了重大贡献，该论文开发了简单方法来提高液体环境中的信噪比，通过选择性增强悬臂梁模式，这将带来更精确的定量测量。
