Huang Chih-Sheng, Yang Shung-Haur, Lin Chun-Chi, Lan Yuan-Tsiu, Chang Shin-Ching, Wang Huann-Sheng, Chen Wei-Shone, Lin Tzu-Chen, Lin Jen-Kou, Jiang Jeng-Kai
Hepatogastroenterology. 2015 Jun;62(140):838-42.
BACKGROUND/AIMS: This study aimed to investigate the clinicopathological characteristics of synchronous and metachronous colorectal cancers (CRCs).
From January 1, 2001 to December 31, 2010, 5898 patients who underwent surgical resection for CRCs were enrolled. Synchronous CRC was defined as presence of more than one primary CRC within 6 months of resection of the primary tumor; while CRC that occurred at least 6 months later was regarded as metachronous CRC.
5346 patients were eligible for the study and divided into three groups: solitary, synchronous and metachronous CRC. The overall prevalence of the synchronous CRC was 2.2% and the 10-year cumulative incidence of metachronous cancer was 0.84%. 29 (64%) metachronous cancers were diagnosed within 3 years of the index cancer and the mean time interval was 3.2 years. Male gender and presence of associated adenoma were significant risk factors for both synchronous and metachronous CRC. Synchronous and metachronous CRC patients shared similar clinicopathological features except that the former were older than the latter by 3.7 years. The five-year survival rates were not different among the three groups.
Our study indicates that synchronous and metachronous CRC might represent similar disease entity with different courses.
背景/目的：本研究旨在调查同时性和异时性结直肠癌（CRC）的临床病理特征。
选取2001年1月1日至2010年12月31日期间接受CRC手术切除的5898例患者。同时性CRC定义为在原发性肿瘤切除后6个月内存在一个以上原发性CRC；而至少6个月后发生的CRC被视为异时性CRC。
5346例患者符合研究条件，分为三组：孤立性、同时性和异时性CRC。同时性CRC的总体患病率为2.2%，异时性癌的10年累积发病率为0.84%。29例（64%）异时性癌在索引癌后3年内被诊断出，平均时间间隔为3.2年。男性性别和相关腺瘤的存在是同时性和异时性CRC的重要危险因素。同时性和异时性CRC患者具有相似的临床病理特征，只是前者比后者大3.7岁。三组的五年生存率无差异。
我们的研究表明，同时性和异时性CRC可能代表具有不同病程的相似疾病实体。
