[癌基因与恶性血液病]
[Oncogenes and malignant hemopathies].
作者信息
Pogliani E M, Bregani E R, Corneo G
出版信息
Recenti Prog Med. 1989 Oct;80(10):526-30.
PMID:2690219
Abstract
In the last ten years molecular biology has defined the role of oncogenes in the pathogenesis of malignant blood diseases. Included among these are: chronic myelogenous leukemia, with abl oncogene; Burkitt's lymphoma, where myc oncogene is translocated from chromosome 8 to chromosomes 2, 14 or 22 near immunoglobulin genes; some acute myelogenous leukemias; myelodysplastic syndromes with deletion of the long arm of chromosome 5.
摘要
在过去十年中，分子生物学已明确了癌基因在恶性血液病发病机制中的作用。其中包括：伴有abl癌基因的慢性粒细胞白血病；伯基特淋巴瘤，其myc癌基因从8号染色体易位至靠近免疫球蛋白基因的2号、14号或22号染色体；一些急性髓细胞白血病；伴有5号染色体长臂缺失的骨髓增生异常综合征。
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