Tan Joyce Zhen Yin, Kwan Yu Heng
Department of Pharmacy, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore 768828, Republic of Singapore.
Saudi Pharm J. 2016 Jan;24(1):21-8. doi: 10.1016/j.jsps.2014.02.002. Epub 2014 Feb 25.
The prevalence of chronic diseases is increasing in Asia, therefore compliance to the medications is of utmost importance to slow disease progression and improve outcomes. Dosage administration aids (DAAs) serve as important tool to improve the compliance of patients. However, there is a dearth of data on the stability of chronic medications in DAAs. Furthermore, data presented by our Western counterparts may not be applicable to us because of our extreme humidity and temperature. In this study, we aim to summarize the data available in the literature on the stability of chronic medications in DAA.
We performed a literature search using electronic databases and related keywords.
In total, 24,336 articles were retrieved and 21 articles were found to be relevant to our topic. This commentary stratified drugs according to their treatment categories and key stability conclusions, DAA and conditions used and recommendations were presented.
Due to the lack of specific data, pharmacists have to exercise their professional judgment with the help from professional guidelines when using DAA in repackaging medication. Manufacturers and regulators can play a greater role in filling the gap needed to provide pharmacists with necessary information to fulfill their function.
亚洲慢性病的患病率正在上升，因此药物依从性对于减缓疾病进展和改善治疗效果至关重要。剂量给药辅助工具（DAAs）是提高患者依从性的重要工具。然而，关于DAAs中慢性药物稳定性的数据却很匮乏。此外，由于我们这里湿度和温度极高，西方同行提供的数据可能不适用于我们。在本研究中，我们旨在总结文献中关于DAAs中慢性药物稳定性的可用数据。
我们使用电子数据库和相关关键词进行了文献检索。
总共检索到24336篇文章，发现其中21篇与我们的主题相关。本评论根据药物的治疗类别、关键稳定性结论、使用的DAA和条件进行了分层，并给出了建议。
由于缺乏具体数据，药剂师在使用DAAs重新包装药物时必须在专业指南的帮助下运用其专业判断力。制造商和监管机构可以在填补空白方面发挥更大作用，为药剂师提供履行其职能所需的必要信息。
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