Kontis Elissaios, Vezakis Antonios, Pantiora Eirini, Stasinopoulou Sotiria, Polydorou Andreas, Voros Dionysios, Fragulidis Georgios P
2nd Department of Surgery, Aretaieio Hospital, University of Athens, School of Medicine, Athens, Greece.
Department of Pathology, Aretaieio Hospital, University of Athens, School of Medicine, Athens, Greece.
Ann Med Surg (Lond). 2015 Oct 26;4(4):434-7. doi: 10.1016/j.amsu.2015.10.013. eCollection 2015 Dec.
Merkel cell carcinoma (MCC) is a rare skin malignancy associated with sun exposure and considered as a Neuroendocrine Tumor due to its characteristic histologic features. However there is increasing number of reports of Unknown Primary MCC's (UPMCC). Although initially UPMCC was considered a variant of known primary MCC, there is growing evidence that it could represent a different clinical entity. We present the case of a 60 year-old male patient who was referred to our department for surgical management of lymph node disease for UPMCC. The patient had undergone excisional biopsy of an inguinal lump, which was found to be an infiltrated lymph node by MCC. The patient underwent full imaging staging including a PET/CT, which failed to identify a primary site, and revealed only intra-abdominal lymph node disease. The patient underwent extended retroperitoneal and inguinal lymph node dissection and remains free of recurrence 16 months postoperatively.
默克尔细胞癌（MCC）是一种与日晒相关的罕见皮肤恶性肿瘤，因其特征性组织学特征被视为神经内分泌肿瘤。然而，原发性不明的MCC（UPMCC）的报告数量日益增加。尽管最初UPMCC被认为是已知原发性MCC的一种变体，但越来越多的证据表明它可能代表一种不同的临床实体。我们报告一例60岁男性患者，因UPMCC的淋巴结疾病被转诊至我科接受手术治疗。患者接受了腹股沟肿块的切除活检，结果发现是MCC浸润的淋巴结。患者接受了包括PET/CT在内的全面影像学分期检查，未发现原发部位，仅显示腹内淋巴结疾病。患者接受了扩大的腹膜后和腹股沟淋巴结清扫术，术后16个月无复发。
