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自身免疫性溶血性贫血与霍奇金病:一种不寻常的儿科关联。

Autoimmune Hemolytic Anemia and Hodgkin's Disease: An Unusual Pediatric Association.

作者信息

Gomes Maria Miguel, Oliva Tereza, Pinto Armando

机构信息

Department of Pediatrics, Hospital de Braga, Sete Fontes, São Victor, 4710-243 Braga, Portugal.

Department of Pediatrics, Portuguese Oncology Institute of Porto Francisco Gentil, 4200-072 Porto, Portugal.

出版信息

Case Rep Pediatr. 2016;2016:4598587. doi: 10.1155/2016/4598587. Epub 2016 Jan 19.

Abstract

Autoimmune hemolytic anemia (AIHA) is a recognized complication of lymphoproliferative disorders. AIHA associated with Hodgkin's disease (HD) is uncommon especially in the pediatric population. The diagnosis of AIHA is usually associated with HD at the time of initial presentation or during the course of disease, but it could precede it by years to months. In adults the association of AIHA and HD is more frequent in advanced stages and in the nodular sclerosis and mixed cellularity type HD. Warm immune hemolytic anemia is mainly controlled with steroids and chemotherapy. We report a case of a pediatric patient with direct antiglobulin positive test at the diagnosis of a late relapse of stage III B mixed cellularity type HD.

摘要

自身免疫性溶血性贫血(AIHA)是淋巴增殖性疾病公认的并发症。与霍奇金淋巴瘤(HD)相关的AIHA并不常见,尤其是在儿科人群中。AIHA的诊断通常与HD在初次就诊时或疾病过程中相关,但也可能在HD之前数年至数月出现。在成人中,AIHA与HD的关联在晚期以及结节硬化型和混合细胞型HD中更为常见。温抗体型自身免疫性溶血性贫血主要通过类固醇和化疗进行控制。我们报告了一例儿科患者,在诊断为III B期混合细胞型HD晚期复发时直接抗球蛋白试验呈阳性。

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Autoimmune hemolytic anemia.自身免疫性溶血性贫血
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