Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania; Chronic Pain Research Consortium, Duquesne University, Pittsburgh, Pennsylvania.
Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania; Chronic Pain Research Consortium, Duquesne University, Pittsburgh, Pennsylvania.
J Urol. 2016 Jul;196(1):24-32. doi: 10.1016/j.juro.2015.10.198. Epub 2016 Feb 22.
Chronic bladder pain is a debilitating condition often accompanied by alterations in affective and autonomic function. Many symptoms associated with chronic bladder pain are mediated by the central nervous system. In this review data from preclinical animal models and human neuroimaging studies were analyzed and a theoretical supraspinal bladder pain network was generated.
We comprehensively reviewed the literature using PubMed® and Google Scholar™. Relevant reviews and original research articles, and the cited references were summarized and then organized on a neuroanatomical basis.
The brain loci the most predominant in the bladder pain literature are the thalamus, parabrachial nucleus, cerebral cortex, amygdala, hypothalamus, periaqueductal gray and rostral ventromedial medulla. This review highlights each of these regions, discussing the molecular and physiological changes that occur in each in the context of bladder pain.
A complex network of brain loci is involved in bladder pain modulation. Studying these brain regions and the changes that they undergo during the transition from acute to chronic bladder pain will provide novel therapeutic strategies for patients with chronic bladder pain diseases such as interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome.
慢性膀胱疼痛是一种使人虚弱的疾病，常伴有情感和自主功能的改变。许多与慢性膀胱疼痛相关的症状是由中枢神经系统介导的。在这篇综述中，分析了来自临床前动物模型和人类神经影像学研究的数据，并生成了一个理论性的脊髓上膀胱疼痛网络。
我们使用 PubMed®和 Google Scholar™ 进行了全面的文献回顾。总结了相关的综述和原始研究文章以及引用的参考文献，并根据神经解剖学进行了组织。
在膀胱疼痛文献中最主要的大脑部位是丘脑、臂旁核、大脑皮层、杏仁核、下丘脑、导水管周围灰质和头侧吻侧髓质。这篇综述强调了这些区域中的每一个，讨论了在从急性到慢性膀胱疼痛的转变过程中每个区域发生的分子和生理变化。
一个涉及膀胱疼痛调节的复杂大脑部位网络。研究这些大脑区域以及它们在从急性到慢性膀胱疼痛的转变过程中所经历的变化，将为间质性膀胱炎/膀胱疼痛综合征和慢性前列腺炎/慢性骨盆疼痛综合征等慢性膀胱疼痛疾病的患者提供新的治疗策略。
