Ladwiniec Andrew, Ettelaie Camille, Cunnington Michael S, Rossington Jennifer, Thackray Simon, Alamgir Farquad, Hoye Angela
aDepartment of Academic Cardiology, Castle Hill Hospital bHull York Medical School cDepartment of Biological Sciences, University of Hull dDepartment of Cardiology, Castle Hill Hospital, Kingston-upon-Hull, UK.
Coron Artery Dis. 2016 Jun;27(4):287-94. doi: 10.1097/MCA.0000000000000360.
In the presence of a chronically occluded coronary artery, the collateral circulation matures by a process of arteriogenesis; however, there is considerable variation between individuals in the functional capacity of that collateral network. This could be explained by differences in endothelial health and function. We aimed to examine the relationship between the functional extent of collateralization and levels of biomarkers that have been shown to relate to endothelial health.
We measured four potential biomarkers of endothelial health in 34 patients with mature collateral networks who underwent a successful percutaneous coronary intervention (PCI) for a chronic total coronary occlusion (CTO) before PCI and 6-8 weeks after PCI, and examined the relationship of biomarker levels with physiological measures of collateralization.
We did not find a significant change in the systemic levels of sICAM-1, sE-selectin, microparticles or tissue factor 6-8 weeks after PCI. We did find an association between estimated retrograde collateral flow before CTO recanalization and lower levels of sICAM-1 (r=0.39, P=0.026), sE-selectin (r=0.48, P=0.005) and microparticles (r=0.38, P=0.03).
Recanalization of a CTO and resultant regression of a mature collateral circulation do not alter systemic levels of sICAM-1, sE-selectin, microparticles or tissue factor. The identified relationship of retrograde collateral flow with sICAM-1, sE-selectin and microparticles is likely to represent an association with an ability to develop collaterals rather than their presence and extent.
在存在慢性闭塞冠状动脉的情况下，侧支循环通过动脉生成过程成熟；然而，个体之间该侧支循环网络的功能能力存在相当大的差异。这可能是由内皮健康和功能的差异所解释。我们旨在研究侧支循环功能范围与已被证明与内皮健康相关的生物标志物水平之间的关系。
我们在34例具有成熟侧支循环网络的患者中测量了四种潜在的内皮健康生物标志物，这些患者在经皮冠状动脉介入治疗（PCI）前因慢性完全冠状动脉闭塞（CTO）接受了成功的PCI，并在PCI后6 - 8周进行了测量，并检查了生物标志物水平与侧支循环生理指标之间的关系。
我们未发现PCI后6 - 8周时sICAM - 1、sE - 选择素、微粒或组织因子的全身水平有显著变化。我们确实发现CTO再通前估计的逆向侧支血流与较低水平的sICAM - 1（r = 0.39，P = 0.026）、sE - 选择素（r = 0.48，P = 0.005）和微粒（r = 0.38，P = 0.03）之间存在关联。
CTO再通及由此导致的成熟侧支循环消退不会改变sICAM - 1、sE - 选择素、微粒或组织因子的全身水平。所确定的逆向侧支血流与sICAM - 1、sE - 选择素和微粒之间的关系可能代表与侧支循环发育能力的关联，而非其存在和范围。
