谜团解开：海藻糖通过阻断葡萄糖转运来启动自噬。
Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport.
作者信息
Mardones Pablo, Rubinsztein David C, Hetz Claudio
机构信息
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile. Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK.
出版信息
Sci Signal. 2016 Feb 23;9(416):fs2. doi: 10.1126/scisignal.aaf1937.
Although vertebrates cannot synthesize the natural disaccharide trehalose, exogenous administration of trehalose to mammalian cells may be beneficial for protein misfolding disorders. In this issue, DeBosch et al. show that trehalose may also be useful in treating nonalcoholic fatty liver disease and identify inhibition of cellular glucose import through SLC2A (also known as GLUT) transporters as a mechanism by which trehalose stimulates autophagy through the adenosine monophosphate-activated protein kinase (AMPK).
尽管脊椎动物无法合成天然二糖海藻糖，但向哺乳动物细胞外源施用海藻糖可能对蛋白质错误折叠疾病有益。在本期中，德博施等人表明，海藻糖在治疗非酒精性脂肪性肝病方面可能也有用，并确定通过溶质载体家族2成员A（SLC2A，也称为葡萄糖转运蛋白）转运体抑制细胞葡萄糖摄取是海藻糖通过腺苷酸活化蛋白激酶（AMPK）刺激自噬的一种机制。
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