Hoang Tony A, Macdonnell Jacqueline E, Mangan Michelle C, Monsour Cindy S, Polwattage Buddhika L, Wilson Sarah F, Suheimat Marwan, Atchison David A
*BVisSc, MOptom †PhD ‡DSc School of Optometry & Vision Sciences and Institute of Health & Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia (all authors).
Optom Vis Sci. 2016 Jun;93(6):594-9. doi: 10.1097/OPX.0000000000000837.
To investigate the time course of pupil centration after application of common topical ocular drugs.
Single drops of 2.5% phenylephrine hydrochloride, 1% tropicamide, and 2% pilocarpine hydrochloride were applied on different days to the right eyes of 12 participants. Anterior eye images were captured, at 5-min intervals for an hour, using an infrared-sensitive camera. The images were analyzed to determine pupil diameter and pupil center, the latter with respect to the limbal center. As a control, natural pupil size and pupil center were determined under different illuminances.
Pupil centers of natural pupils shifted temporally as pupils dilated. At common pupil sizes, drug-induced pupil centers were different from natural pupil centers. Phenylephrine produced a center shift in the nasal and inferior directions that peaked after a mean of 30 min, whereas dilation was continuing up to 60 min. Tropicamide produced transient center shifts in the nasal and inferior directions that peaked at about 10 min before reducing toward baseline values, whereas dilation reached a peak at about 25 min. Pilocarpine produced a small sustained superior shift that, like constriction, reached a peak after about 25 min.
Application of topical ophthalmic drugs cause shifts in pupil center that do not match those produced by natural changes in pupil size and that, in the cases of phenylephrine and tropicamide, follow a different time course than the pupil size changes.
研究应用常见局部眼用药物后瞳孔对中的时间进程。
在不同日期，将2.5%盐酸去氧肾上腺素、1%托吡卡胺和2%盐酸毛果芸香碱的单滴药液滴入12名受试者的右眼。使用红外敏感相机每隔5分钟拍摄一次眼前部图像，持续一小时。对图像进行分析以确定瞳孔直径和瞳孔中心，后者相对于角膜缘中心。作为对照，在不同光照条件下确定自然瞳孔大小和瞳孔中心。
自然瞳孔的瞳孔中心随着瞳孔扩张而向颞侧移动。在常见瞳孔大小下，药物诱导的瞳孔中心与自然瞳孔中心不同。去氧肾上腺素使瞳孔中心向鼻侧和下方移位，平均30分钟后达到峰值，而瞳孔扩张一直持续到60分钟。托吡卡胺使瞳孔中心在鼻侧和下方产生短暂移位，在约10分钟时达到峰值，然后向基线值回落，而瞳孔扩张在约25分钟时达到峰值。毛果芸香碱使瞳孔产生持续的小幅向上移位，与瞳孔收缩一样，在约25分钟后达到峰值。
局部应用眼科药物会导致瞳孔中心移位，这种移位与瞳孔大小自然变化所产生的移位不匹配，并且在去氧肾上腺素和托吡卡胺的情况下，其时间进程与瞳孔大小变化不同。
