Senoo Hiroshi, Sesaki Hiromi, Iijima Miho
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Dev Cell. 2016 Feb 22;36(4):354-6. doi: 10.1016/j.devcel.2016.02.006.
In this issue of Developmental Cell, Pan et al. (2016) identified in cells of the social amoeba Dictyostelium a G protein-coupled receptor (GPCR) that recognizes a chemoattractant secreted by bacteria. This work uncovers a mechanism by which a single GPCR mediates pseudopod extension during cell migration and bacterial engulfment.
在本期《发育细胞》杂志中,潘等人(2016年)在社会性变形虫盘基网柄菌的细胞中鉴定出一种G蛋白偶联受体(GPCR),该受体可识别细菌分泌的趋化因子。这项工作揭示了一种机制,即单个GPCR在细胞迁移和细菌吞噬过程中介导伪足延伸。