Shah Lokesh, Mainelis Gediminas, Ramagopal Maya, Black Kathleen, Shalat Stuart L
Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Department of Environmental Sciences, Rutgers The State University of New Jersey, New Brunswick, NJ 08901, USA.
Int J Environ Res Public Health. 2016 Feb 19;13(2):242. doi: 10.3390/ijerph13020242.
While the association of eczema with asthma is well recognized, little research has focused on the potential role of inhalable exposures and eczema. While indoor air quality is important in the development of respiratory disease as children in the U.S. spend the majority of their time indoors, relatively little research has focused on correlated non-respiratory conditions. This study examined the relationship between particulate matter (PM) exposures in preschool age children and major correlates of asthma, such as wheeze and eczema. Air sampling was carried out using a robotic (PIPER) child-sampling surrogate. This study enrolled 128 participants, 57 male and 71 female children. Ages ranged from 3 to 58 months with the mean age of 29.3 months. A comparison of subjects with and without eczema showed a difference in the natural log (ln) of PM collected from the PIPER air sampling (p = 0.049). PIPER's sampling observed an association between the ln PM concentrations and eczema, but not an association with wheezing history in pre-school children. Our findings are consistent with the hypothesis of the role of the microenvironment in mediating atopic dermatitis, which is one of the predictors of persistent asthma. Our findings also support the use of PIPER in its ability to model and sample the microenvironment of young children.
虽然湿疹与哮喘之间的关联已得到充分认识，但很少有研究关注可吸入暴露因素与湿疹的潜在关系。尽管室内空气质量在美国儿童呼吸道疾病的发生发展中起着重要作用，因为美国儿童大部分时间都待在室内，但相对较少的研究关注与之相关的非呼吸道疾病。本研究调查了学龄前儿童的颗粒物（PM）暴露与哮喘的主要相关因素（如喘息和湿疹）之间的关系。使用机器人（PIPER）儿童采样替代装置进行空气采样。本研究招募了128名参与者，其中57名男童和71名女童。年龄范围为3至58个月，平均年龄为29.3个月。对有湿疹和无湿疹的受试者进行比较，结果显示从PIPER空气采样中收集的PM的自然对数（ln）存在差异（p = 0.049）。PIPER的采样观察到ln PM浓度与湿疹之间存在关联，但与学龄前儿童的喘息病史无关。我们的研究结果与微环境在介导特应性皮炎（持续性哮喘的预测因素之一）中所起作用的假设一致。我们的研究结果还支持PIPER在模拟和采样幼儿微环境方面的能力。
