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连续性静脉-静脉血液透析滤过在异环磷酰胺所致脑病治疗中的应用:一例报告

The Use of Continuous Veno-Venous Hemodiafiltration in the Management of Ifosfamide-induced Encephalopathy: A Case Report.

作者信息

Yeo Kee Kiat, HaDuong Josephine H

机构信息

*Children's Center for Cancer and Blood Diseases, Division of Hematology, Oncology and Blood & Marrow Transplantation, Children's Hospital Los Angeles †Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA.

出版信息

J Pediatr Hematol Oncol. 2016 Aug;38(6):489-90. doi: 10.1097/MPH.0000000000000527.

DOI:10.1097/MPH.0000000000000527
PMID:26907647
Abstract

Encephalopathy is a common side effect of ifosfamide, occurring in up to 30% of patients. Although self-resolving in most cases, death secondary to severe encephalopathy has been reported. Methylene blue and thiamine have been occasionally successful as treatment. We report a case of an 11-year-old girl with relapsed neuroblastoma who developed grade 4 ifosfamide-induced encephalopathy. She showed no initial response to methylene blue and thiamine. She remained neurologically impaired and continuous veno-venous hemodiafiltration was started, with rapid resolution of encephalopathy. This is the first report of continuous veno-venous hemodiafiltration use for suspected ifosfamide-induced encephalopathy in the pediatric population.

摘要

脑病是异环磷酰胺常见的副作用,高达30%的患者会出现。虽然大多数情况下可自行缓解,但也有继发于严重脑病而死亡的报道。亚甲蓝和硫胺偶尔治疗成功。我们报告一例11岁复发性神经母细胞瘤女孩,发生了4级异环磷酰胺诱导的脑病。她最初对亚甲蓝和硫胺无反应。她仍有神经功能损害,遂开始持续静静脉血液透析滤过,脑病迅速缓解。这是儿科人群中疑似异环磷酰胺诱导的脑病使用持续静静脉血液透析滤过的首例报告。

相似文献

1
The Use of Continuous Veno-Venous Hemodiafiltration in the Management of Ifosfamide-induced Encephalopathy: A Case Report.连续性静脉-静脉血液透析滤过在异环磷酰胺所致脑病治疗中的应用:一例报告
J Pediatr Hematol Oncol. 2016 Aug;38(6):489-90. doi: 10.1097/MPH.0000000000000527.
2
Ifosfamide-induced neurotoxicity reversal with continuous veno-venous hemodialysis. A case report.连续性静脉-静脉血液透析逆转异环磷酰胺所致神经毒性。1例报告。
J Oncol Pharm Pract. 2013 Sep;19(3):261-4. doi: 10.1177/1078155212459285. Epub 2012 Nov 7.
3
[Methylene blue in ifosfamide-induced encephalopathy].[亚甲蓝治疗异环磷酰胺所致脑病]
Dtsch Med Wochenschr. 1996 Sep 27;121(39):1210.
4
Hydration, methylene blue, and thiamine as a prevention regimen for ifosfamide-induced encephalopathy.水化、亚甲蓝和硫胺作为异环磷酰胺所致脑病的预防方案。
J Oncol Pharm Pract. 2019 Oct;25(7):1784-1786. doi: 10.1177/1078155218808361. Epub 2018 Oct 22.
5
[Treatment of ifosfamide induced encephalopathy with methylene-blue].[亚甲蓝治疗异环磷酰胺诱发的脑病]
Bull Cancer. 1995 Jul;82(7):598-9.
6
Ifosfamide-induced Encephalopathy With Rapid Response to Thiamine: A Pediatric Case.异环磷酰胺诱发的脑病对硫胺素反应迅速:一例儿科病例
J Pediatr Hematol Oncol. 2022 Oct 1;44(7):402-404. doi: 10.1097/MPH.0000000000002473. Epub 2022 May 2.
7
Methylene blue and the neurotoxic mechanisms of ifosfamide encephalopathy.亚甲蓝与异环磷酰胺脑病的神经毒性机制
Eur J Clin Pharmacol. 1996;50(4):249-52. doi: 10.1007/s002280050102.
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[Ifosfamide induced encephalopathy: 15 observations].[异环磷酰胺诱发的脑病:15例观察]
Arch Pediatr. 2006 Feb;13(2):140-5. doi: 10.1016/j.arcped.2005.10.021. Epub 2005 Dec 20.
9
Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.亚甲蓝治疗和预防异环磷酰胺所致脑病:12例报告及文献复习
Br J Cancer. 2000 Jan;82(2):291-4. doi: 10.1054/bjoc.1999.0917.
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[Successful treatment with methylene blue of ifosfamide-induced central nervous system effects].[亚甲蓝成功治疗异环磷酰胺引起的中枢神经系统效应]
Dtsch Med Wochenschr. 1996 Apr 26;121(17):575.

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