Department of Radiology, University of Pittsburgh - UPMC Presbyterian Shadyside - Radiology, Suite 200 East Wing 200 Lothrop Street, Pittsburgh, PA, 15213, USA.
Abdom Radiol (NY). 2016 Jul;41(7):1399-410. doi: 10.1007/s00261-016-0685-z.
Gadoxetate disodium (Gd-EOB-DTPA) is a linear, non-ionic paramagnetic MR contrast agent with combined extracellular and hepatobiliary properties commonly used for several liver indications. Although gadoxetate disodium is commonly used for detection and characterization of focal lesions, a spectrum of diffuse disease processes can affect the hepatobiliary phase of imaging (i.e., when contrast accumulates within the hepatocytes). Non-focal signal abnormalities during the hepatobiliary phase can be seen with multiple disease processes such as deposition disorders, infiltrating tumors, vascular diseases, and post-treatment changes. The purpose of this paper is to review the different processes which result in non-focal signal alteration during the hepatobiliary phase and to describe imaging patterns that may order a differential diagnosis and facilitate patient management.
钆塞酸二钠（Gd-EOB-DTPA）是一种线性、非离子型顺磁性磁共振对比剂，具有细胞外和肝胆双重特性，常用于多种肝脏适应证。虽然钆塞酸二钠常用于局灶性病变的检测和特征描述，但一系列弥漫性疾病过程也会影响肝胆期成像（即对比剂在肝细胞内积聚时）。多种疾病过程可导致肝胆期出现非局灶性信号异常，如沉积性疾病、浸润性肿瘤、血管性疾病和治疗后改变等。本文旨在回顾导致肝胆期出现非局灶性信号改变的不同过程，并描述可能有助于鉴别诊断和指导患者管理的影像学表现。
