O'Brien Travis J, LeLacheur Susan, Ward Caitlin, Lee Norman H, Callier Shawneequa, Harralson Arthur F
Department of Pharmacology & Physiology, The George Washington University School of Medicine & Health Sciences, Washington, DC 20037, USA.
Department of Physician Assistant Studies, The George Washington University School of Medicine & Health Sciences, Washington, DC 20037, USA.
Pharmacogenomics. 2016 Mar;17(4):341-52. doi: 10.2217/pgs.15.182. Epub 2016 Feb 24.
We assessed the impact of personal CYP2D6 testing on physician assistant student competency in, and attitudes toward, pharmacogenetics (PGx).
MATERIALS & METHODS: Buccal samples were genotyped for CYP2D6 polymorphisms. Results were discussed during a 3-h PGx workshop. PGx knowledge was assessed by pre- and post-tests. Focus groups assessed the impact of the workshop on attitudes toward the clinical utility of PGx.
Both student knowledge of PGx, and its perceived clinical utility, increased immediately following the workshop. However, exposure to PGx on clinical rotations following the workshop seemed to influence student attitudes toward PGx utility.
Personal CYP2D6 testing improves both knowledge and comfort with PGx. Continued exposure to PGx concepts is important for transfer of learning.
我们评估了个人CYP2D6检测对医师助理学生在药物遗传学（PGx）方面的能力及态度的影响。
对颊拭子样本进行CYP2D6多态性基因分型。在一场3小时的PGx研讨会上讨论结果。通过前后测试评估PGx知识。焦点小组评估了该研讨会对PGx临床效用态度的影响。
研讨会结束后，学生对PGx的知识及其感知到的临床效用立即增加。然而，研讨会后在临床轮转中接触PGx似乎影响了学生对PGx效用的态度。
个人CYP2D6检测提高了对PGx的知识和接受度。持续接触PGx概念对于学习的迁移很重要。
