López Carolina S, Saka Constanza H, Rada Gabriel, Valenzuela Daniela D
Faculty of Medicine, Pontificia Universidad Católica de Chile.
Department of Internal Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile Evidence-based Health Care Program, Faculty of Medicine, Pontificia Universidad Católica de Chile Epistemonikos foundation, Santiago, Chile.
BMJ Open. 2016 Feb 23;6(2):e009288. doi: 10.1136/bmjopen-2015-009288.
Edentulism is a debilitating and irreversible condition described as the 'final marker of disease burden for oral health'. Therapy with dental implants is being used on a large scale to replace missing teeth and to rehabilitate edentulous patients with overdentures and implant supported fixed dentures as a method of solving the problem of instability and lack of retention associated with conventional removable prostheses. Fixed implant supported prostheses are an alternative for implant rehabilitation treatment that allow patients to have new fixed teeth. They can be indicated in partial or total edentulous patients, and they can replace single teeth, or teeth and supporting tissues (hybrid prosthesis). They overcome the limitations of conventional dentures, increasing stability and retention, providing functional and psychological advantages for the patients.
We will electronically search for randomised controlled trials evaluating the effects of fixed implant supported prostheses in edentulous patients in the following databases: Pubmed/MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials. We will also try to obtain literature screening references of included studies, searching for trial protocols in the WHO International Clinical Trials Registry Platform, reviewing International Team for Implantology conference proceedings and searching for non-published studies through Open Gray. Two researchers will independently undertake selection of studies, data extraction and assessment of the quality of the included studies. Data synthesis and subgroup analyses will be performed using special Review Manager software. Data will be combined in a meta-analysis using a random effects model.
The results will be presented as risk ratios for dichotomous data, and as mean difference or standardised mean difference for continuous data.
No ethics approval is considered necessary. The results of this study will be disseminated via peer reviewed publications and social networks.
CRD42015022086.
无牙颌是一种使人衰弱且不可逆转的状况，被描述为“口腔健康疾病负担的最终标志”。牙种植体治疗正被广泛用于替代缺失牙，并通过覆盖义齿和种植体支持的固定义齿修复无牙颌患者，以此解决与传统可摘义齿相关的稳定性和固位不足问题。种植体支持的固定义齿是种植修复治疗的一种选择，可让患者拥有新的固定牙齿。它们适用于部分或全部无牙颌患者，可替代单颗牙齿或牙齿及支持组织（混合义齿）。它们克服了传统义齿的局限性，提高了稳定性和固位力，为患者带来功能和心理上的益处。
我们将在以下数据库中进行电子检索，以查找评估种植体支持的固定义齿对无牙颌患者影响的随机对照试验：PubMed/MEDLINE、EMBASE和Cochrane对照试验中央注册库。我们还将尝试获取纳入研究的文献筛选参考文献，在世卫组织国际临床试验注册平台上搜索试验方案，查阅国际口腔种植学会会议论文集，并通过Open Gray搜索未发表的研究。两名研究人员将独立进行研究选择、数据提取和纳入研究质量评估。数据合成和亚组分析将使用专门的Review Manager软件进行。数据将使用随机效应模型合并进行荟萃分析。
结果将以二分类数据的风险比以及连续数据的均值差或标准化均值差呈现。
无需伦理批准。本研究结果将通过同行评审出版物和社交网络进行传播。
CRD42015022086。
