Shim Jinhee, Pérez Adriana, Symanski Elaine, Nyitray Alan G
Department of Business Intelligence and Analytics, Texas Children's Health Plan, Houston.
Department of Biostatistics, University of Texas School of Public Health, Austin.
J Infect Dis. 2016 Jun 15;213(12):1886-92. doi: 10.1093/infdis/jiw065. Epub 2016 Feb 15.
A sufficient level of vitamin D enhances protection against several infectious diseases; however, its association with cervicovaginal human papillomavirus (HPV) infection has not been studied.
Data for this cross-sectional study were from National Health and Nutrition Examination Survey 2003-2006. A total of 2353 sexually active women for whom cervicovaginal HPV infection status and serum 25-hydroxyvitamin D (25[OH]D) level were known were studied. Associations between serum 25(OH)D levels (continuous and categorical forms) and cervicovaginal HPV infection (due to high-risk HPV or vaccine-type HPV) were estimated using weighted logistic regression.
After adjustment for age, race/ethnicity, and marital status, the odds of high-risk HPV infection were increased per each 10 ng/mL decrease in serum 25(OH)D level (adjusted odds ratio [aOR], 1.14; 95% confidence interval [CI], 1.02-1.27). Similarly, the odds of vaccine-type HPV infection were increased in women with vitamin D levels that were severely deficient (serum 25[OH]D level, <12 ng/mL; aOR, 2.90; 95% CI, 1.32-6.38), deficient (12-19 ng/mL; aOR, 2.19; 95% CI, 1.08-4.45), and insufficient (20-29 ng/mL; aOR, 2.19; 95% CI, 1.22-3.93), compared with those with vitamin D levels that were sufficient (≥30 ng/mL).
Cervicovaginal HPV prevalence is associated with less-than-optimal levels of serum vitamin D.
充足的维生素D水平可增强对多种传染病的防护能力；然而，其与宫颈阴道人乳头瘤病毒（HPV）感染之间的关联尚未得到研究。
这项横断面研究的数据来自2003 - 2006年的美国国家健康与营养检查调查。共对2353名有性活动的女性进行了研究，她们的宫颈阴道HPV感染状况和血清25 - 羟基维生素D（25[OH]D）水平已知。使用加权逻辑回归评估血清25(OH)D水平（连续型和分类型）与宫颈阴道HPV感染（高危型HPV或疫苗型HPV所致）之间的关联。
在对年龄、种族/族裔和婚姻状况进行调整后，血清25(OH)D水平每降低10 ng/mL，高危型HPV感染的几率就会增加（调整后的优势比[aOR]为1.14；95%置信区间[CI]为1.02 - 1.27）。同样，与维生素D水平充足（≥30 ng/mL）的女性相比，维生素D水平严重缺乏（血清25[OH]D水平<12 ng/mL；aOR为2.90；95% CI为1.32 - 6.38）、缺乏（12 - 19 ng/mL；aOR为2.19；95% CI为1.08 - 4.45）和不足（20 - 29 ng/mL；aOR为2.19；95% CI为1.22 - 3.93）的女性，疫苗型HPV感染的几率增加。
宫颈阴道HPV感染率与血清维生素D水平未达最佳状态有关。
